info:eu-repo/semantics/article
The paradoxical roles of inflammation during PD-1 blockade in cancer
Fecha
2020-09Registro en:
Hill, Marcelo; Segovia, Mercedes; Russo, Sofía; Girotti, Maria Romina; Rabinovich, Gabriel Adrián; The paradoxical roles of inflammation during PD-1 blockade in cancer; Elsevier; Trends In Immunology; 41; 11; 9-2020; 982-993
1471-4906
CONICET Digital
CONICET
Autor
Hill, Marcelo
Segovia, Mercedes
Russo, Sofía
Girotti, Maria Romina
Rabinovich, Gabriel Adrián
Resumen
Recent studies have reported paradoxical roles of inflammation in tumor immunity triggered by PD-1 checkpoint antibody (Ab) blockade. Here, we elaborate on this controversy and propose a new perspective that might help understand this paradox. Since inflammatory cytokines and PD-1 blockade are known to target different subsets of exhausted CD8+ T cells, we propose that the timing at which anti-PD-1 Ab therapy and cytokine modulation occur might determine the fate of exhausted CD8+ T cells and perhaps, the clinical outcome of immunotherapeutic modalities.