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Control of the Hypoxic Response in Drosophila melanogaster by the Basic Helix-Loop-Helix PAS Protein Similar
(American Society for Microbiology, 2002-10)
In mammalian systems, the heterodimeric basic helix-loop-helix (bHLH)-PAS transcription hypoxia-inducible factor (HIF) has emerged as the key regulator of responses to hypoxia. Here we define a homologous system in Drosophila ...
The β-scaffold of the LOV domain of the brucella light-activated histidine kinase is a key element for signal transduction
(Academic Press Ltd - Elsevier Science Ltd, 2012-06)
Light-oxygen-voltage (LOV) domains are blue-light-activated signaling modules present in a wide range of sensory proteins. Among them, the histidine kinases are the largest group in prokaryotes (LOV-HK). Light modulates ...
Molecular modelling predicts that 2-methoxyestradiol disrupts HIF function by binding to the PAS-B domain
(Elsevier Inc., 2019)
An estradiol metabolite, 2-methoxyestradiol (2ME), has emerged as an important regulator of ovarian physiology. 2ME is recognized as a potent anti-angiogenic agent in clinical trials and laboratory studies. However, little ...
Graphene to graphane: a theoretical study
(Iop Publishing LtdBristolInglaterra, 2009)
Efeitos da idade no desempenho de uma amostra brasileira saudável no Teste Faux Pas de Teoria da Mente (ToM)
(Universidade Federal de São Paulo (UNIFESP), 2018-09-27)
Abstract: Introduction: Theory of Mind (ToM) is the capacity to infer a thought, mental
states for himself and for others. There are two different components to be observed
in ToM: the affective (ToM-a), in which the ...
Fin d'un mythe géologique moderne: Il n'y a pas de rudistes au Brésil! et ses implications paléobiogéographiques
(2015-07-14)
Out of the few records of rudists from the Cretaceous strata of the South Atlantic coastal basins only two refer to Brazilian localities. However, petrographic analyses demonstrate that these shells should be assigned to ...
Expansão da rede de unidades de conservação da Mata Atlântica e sua eficacia para a proteção das fitofisionomias e espécies de primatas: análises em sistemas de informação geografica
(Universidade Federal de Minas GeraisUFMG, 2010-05-31)
In the last century, massive investments towards biodiversity conservation were applied to the Atlantic forest, particularly for protected areas (PA) creation and management. However, the evaluation of the achivemnets of ...
Hypoxia-Inducible Factor (HIF): Fuel for Cancer Progression
(Bentham Science Publ. LTD, 2021)
Hypoxia is an integral part of the tumor microenvironment, caused primarily due to rapidly multiplying tumor cells and a lack of proper blood supply. Among the major hypoxic pathways, HIF-1 transcription factor activation ...