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MAPKs and signal transduction in the control of gastrointestinal epithelial cell proliferation and differentiation
(MDPIBasel, 2013-05-13)
Mitogen-activated protein kinase (MAPK) pathways are activated by several stimuli and transduce the signal inside cells, generating diverse responses including cell proliferation, differentiation, migration and apoptosis. ...
O papel da via de sinalização p38 MAPK no desenvolvimento do Schistosoma mansoni (Platyhelminthes:Trematoda) e na proteção contra o estresse oxidativo
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOLOGIA GERALPrograma de Pós-Graduação em GenéticaUFMG, 2013-08-30)
There are three important Schistosoma species parasitizing humans: Schistosoma
mansoni, S. japonicum and S. haematobium. Together, they are responsible for the chronic
infection of 200 million people and over 200,000 ...
Systematic review of p38 mitogen-activated kinase and its functional role in reproductive tissues
(2018-01-01)
Oxidative stress (OS) plays a role in uterine tissue remodeling during pregnancy and parturition. While p38 MAPK is an OS-response kinase, a precise functional role is unknown. Therefore, we conducted a systematic review ...
Role of estrogen receptors, PKC and Src in ERK2 and p38 MAPK signaling triggered by 17β-estradiol in skeletal muscle cells
(Pergamon-Elsevier Science Ltd, 2010-10)
We have previously reported in C2C12 murine skeletal muscle cells that 10-8M 17β-estradiol promotes MAPKs stimulation which in turn mediates the activation of CREB and Elk-1 transcription factors. In this work, we demonstrated ...
The Potential of p38 MAPK Inhibitors to Modulate Periodontal Infections
(Bentham Science Publ Ltd, 2009-01-01)
Periodontal disease initiation and progression occurs as a consequence of the host immune inflammatory response to oral pathogens. The innate and acquired immune systems are critical for the proper immune response. LPS, ...
The Potential of p38 MAPK Inhibitors to Modulate Periodontal Infections
(Bentham Science Publ Ltd, 2009-01-01)
Periodontal disease initiation and progression occurs as a consequence of the host immune inflammatory response to oral pathogens. The innate and acquired immune systems are critical for the proper immune response. LPS, ...
Envolvimento de p38 MAPK no ciclo de vida do Vaccinia virus
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE MICROBIOLOGIAPrograma de Pós-Graduação em MicrobiologiaUFMG, 2014-02-27)
Viruses rely extensively on host cell functions to complete their lifecycles. During infection, viruses co-opt signaling pathways, key regulators of cell physiology, to achieve an intracellular milieu suitable for productive ...
The role of p38 mitogen-activated protein kinase in serum-induced leukemia inhibitory factor secretion by bone marrow stromal cells from pediatric myelodysplastic syndromes
(PERGAMON-ELSEVIER SCIENCE LTD, 2010)
Stromal cells from pediatric myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) associated with MDS(MDS-AML) present high expression of leukemia inhibitor factor (LIF). We demonstrated using mitogen-activated ...
The Potential of p38 MAPK Inhibitors to Modulate Periodontal Infections
(Bentham Science Publ Ltd, 2013)
Docking, synthesis and pharmacological activity of novel urea-derivatives designed as p38 MAPK inhibitors
(ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERPARIS, 2012)
p38 mitogen-activated protein kinase (p38 MAPK) is an important signal transducing enzyme involved in many cellular regulations, including signaling pathways, pain and inflammation. Several p38 MAPK inhibitors have been ...