Resenha
The Potential of p38 MAPK Inhibitors to Modulate Periodontal Infections
Fecha
2009-01-01Registro en:
Current Drug Metabolism. Sharjah: Bentham Science Publ Ltd, v. 10, n. 1, p. 55-67, 2009.
1389-2002
10.2174/138920009787048347
WOS:000263289600007
Autor
Med Univ S Carolina
Universidade Estadual Paulista (Unesp)
Resumen
Periodontal disease initiation and progression occurs as a consequence of the host immune inflammatory response to oral pathogens. The innate and acquired immune systems are critical for the proper immune response. LPS, an outer membrane constituent of periodontal pathogenic bacteria, stimulates the production of inflammatory cytokines IL-1 beta TNF alpha IL-6 and RANKL either directly or indirectly. In LPS-stimulated cells, the induction of cytokine expression requires activation of several signaling pathways including the p38 MAPK pathway. This review will discuss the significance of the p38 MAPK pathway in periodontal disease progression and the potential therapeutic consequences of pharmacological antagonism of this pathway in the treatment of periodontal diseases.