The radical or radical ion-based fluorination reactions of organic compounds will be presented. These methodologies include fluorination processes accomplished through thermal or photoinduced radical/electron transfer ...

Late Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical ...

Nucleophilic trifluoromethylation and perfluoroalkylation reactions have been the outstanding approach during the last few decades to effect fluoroalkyl group addition or substitution reactions. In most instances, ...

Fluorination reactions of medicinal and biologically-active compounds will be discussed. Late stage fluorination strategies of medicinal targets have recently attracted considerable attention on account of the influence ...

The preparation of N-methylpyrazoles is usually accomplished through reaction of a suitable 1,3-diketone with methylhydrazine in ethanol as the solvent. This strategy, however, leads to the formation of regioisomeric ...

Fluorinated radicals in water are shown to enable a useful array of synthetic organic transformations, reflecting these intermediates' distinct behavior in water or aqueous media. The enhanced reactivities of perfluroalkyl ...