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Mostrando ítems 1-10 de 17
Comparative Kinetic Analysis of OXA-438 with Related OXA-48-Type Carbapenem-Hydrolyzing Class D β-Lactamases
(American Chemical Society, 2020-11)
Novel variants of OXA-48-type enzymes with the ability to hydrolyze oxyimino-cephalosporins and carbapenems are increasingly reported. Since its first report in 2011, OXA-163 is now extensively spread throughout Argentina, ...
Crystal Structure of the Extended-Spectrum β-Lactamase PER-2 and Insights into the Role of Specific Residues in the Interaction with β-Lactams and β-Lactamase Inhibitors
(American Society for Microbiology, 2014-07)
PER-2 belongs to a small (7 members to date) group of extended-spectrum β-lactamases. It has 88% amino acid identity with PER-1 and both display high catalytic efficiencies towards most β-lactams. In this study, we determined ...
Antimicrobial Activity of CXA-101, a Novel Cephalosporin Tested in Combination with Tazobactam against Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides fragilis Strains Having Various Resistance Phenotypes
(Amer Soc Microbiology, 2011-05-01)
CXA-101, a novel oxyimino-aminothiazolyl cephalosporin, CXA-201 (CXA-101 combined with tazobactam), and various comparators were susceptibility tested by broth microdilution methods against 1,301 well-characterized clinical ...
Encuesta a médicos sobre mecanismos de resistencia a oximino-cefalosporinas y carbapenems, y sus opciones terapéuticas en Uruguay
(Udelar. FM, 2021)
Introducción: La resistencia a los antimicrobianos genera preocupación a nivel mundial, la Organización Mundial de la Salud (OMS) en conjunto con la Organización de las Naciones Unidas para la Alimentación y Agricultura ...
Biochemical and Molecular Characterization of Three New Variants of AmpC β-Lactamases from Morganella morganii
(American Society for Microbiology, 2006-03)
Morganella morganii produces an inducible, chromosomally encoded AmpC beta-lactamase. We describe in this study three new variants of AmpC within this species with apparent pIs of 6.6 (M19 from M. morganii strain PP19), ...
Zoonotic potential and antibiotic resistance of Escherichia coli in neonatal calves in Uruguay
(Japanese Soc Microbial Ecology, 2017-09)
Escherichia coli is one of the main etiological agents of neonatal calf diarrhea (NCD). The objective of this study was to assess the presence of virulence genes, genetic diversity, and antibiotic resistance mechanisms in ...
Impact of mutations at Arg220 and Thr237 in PER-2 β-Lactamase on conformation, activity, and susceptibility to inhibitors
(American Society for Microbiology, 2017-06)
PER-2 accounts for up to 10% of oxyimino-cephalosporin resistance in Klebsiella pneumoniae and Escherichia coli in Argentina and hydrolyzes both cefotaxime and ceftazidime with high catalytic efficiencies (kcat/Km). Through ...
Risk factors for community acquired urinary tract infections caused by extended spectrum β-lactamase (ESBL)
(Universidad del RosarioEspecialización en PediatríaFacultad de medicina, 2018)
Extended-spectrum βlactamases (ESBLs)are β-lactamases that hydrolyze extended-spectrum cephalosporins with an oxyimino side chain. These cephalosporins include cefotaxime, ceftriaxone, and ceftazidime, as well as the ...
Detection of class 1 and 2 integrons, extended-spectrum β-lactamases and qnr alleles in enterobacterial isolates from the digestive tract of Intensive Care Unit inpatients
(Elsevier Science, 2010-11)
In this study, we searched for extended-spectrum β-lactamases (ESBLs), class 1 and 2 integrons, and qnrA, qnrB and qnrS genes in 56 oxyimino-cephalosporin and/or ciprofloxacin-resistant enterobacterial isolates obtained ...
Investigação de genes de resistência às quinolonas e aminoglicosídeos em Klebsiella pneumoniae produtoras de carbapenemases do tipo KPC em hospitais do estado de São Paulo
(Universidade Estadual Paulista (UNESP), 2015)