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XTIF2, a Xenopus homologue of the human transcription intermediary factor, is required for a nuclear receptor pathway that also interacts with CBP to suppress Brachyury and XMyoD
(2000)
Ligand-bound nuclear receptors (NRs) recruit cofactors such as members of the p160 family and CREB-binding protein (CBP) to activate transcription. We have cloned the Xenopus homologue of the human transcription intermediary ...
Diverse coactivator recruitment through differential PPARγ nuclear receptor agonism
(Genetics and Molecular Biology, 2013-03-04)
The PPARγ nuclear receptor regulates the expression of genes involved in lipid and carbohydrate metabolism, and it has protective effects in some patients with type 2 diabetes. Nevertheless, the therapeutic value of the ...
Helix 12 dynamics and thyroid hormone receptor activity: experimental and molecular dynamics studies of Ile280 mutants
(ElsevierAmsterdam, 2011-10)
Nuclear hormone receptors (NRs) form a family of transcription factors that mediate cellular responses initiated by hormone binding. It is generally recognized that the structure and dynamics of the C-terminal helix 12 ...
Helix 12 Dynamics and Thyroid Hormone Receptor Activity: Experimental and Molecular Dynamics Studies of Ile280 Mutants
(Academic Press Ltd- Elsevier Science LtdLondonInglaterra, 2011)
A family-based approach reveals the function of residues in the nuclear receptor ligand-binding domain
(Elsevier B.V., 2004-08-06)
Literature studies, 3D structure data, and a series of sequence analysis techniques were combined to reveal important residues in the structure and function of the ligand-binding domain of nuclear hormone receptors. A ...
Mapeamento de cofatores SRC1, NCoR e REA nos testículos, dúctulos eferentes e próstata de ratos
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE MORFOLOGIAPrograma de Pós-Graduação em Biologia CelularUFMG, 2018-03-28)
The male genital system is controlled by sex steroid hormones, among them androgens and estrogens. Their biological effects are mediated by the androgen (AR) and estrogen (ERα and ERβ) receptors, members of the nuclear ...
Fitoligantes derivados de plantas medicinais e ativação do receptor do hormônio tireoidiano
(Instituto de LetrasPrograma de Pós-Graduação em Letras e LingüísticaUFBAbrasil, 2019-02-21)
Os receptores nucleares (RN) fazem parte de uma superfamília de fatores de transcrição
que são ativos mediante interação com ligantes e controlam amplamente a fisiologia
humana através do controle da expressão gênica. ...
Correlación del índice de masa corporal (IMC) con la expresión del ARNm de receptores nucleares en tejido adiposo de mujeres con IMC de entre 18.5 en adelante
(2011-11-28)
Obesity is a chronic, complex and multifactorial induced genetic and environmental
components, an obese person is at risk for many diseases and health problems. Today,
Mexico ranks first inchildhood obesity and adult ...
The pregnane X receptor (PXR) and the nuclear receptor corepressor 2 (NCoR2) modulate cell growth in head and neck squamous cell carcinoma
(Public Library of Science, 2018-02)
Head and neck squamous cell carcinoma (HNSCC) is the sixth most frequent cancer worldwide. The pregnane X receptor (PXR) is a nuclear receptor regulating several target genes associated with cancer malignancy. We here ...
Unraveling the molecular interactions involved in phase separation of glucocorticoid receptor
(BioMed Central, 2020-06)
Background: Functional compartmentalization has emerged as an important factor modulating the kinetics and specificity of biochemical reactions in the nucleus, including those involved in transcriptional regulation. The ...