Renal damage due to urinary tract obstruction accounts for up to 30% of acute kidney injury in paediatrics and adults. Bilateral ureteral obstruction (BUO) is associated with polyuria and reduced urinary concentrating ...

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Epilepsy is a chronic disease characterized by periodic and unpredictable occurrence of seizures, due to high neuronal activity, product of a dysregulation of excitatory and inhibitory activity. Studies in neurons ...

The increase in hippocampal excitability is one of the cardinal symptoms of temporal lobe epilepsy (TLE), the most common epilepsy type. In epileptic patients as well as animal models have been observed an increase in ...

Granule cells of the dentate gyrus (GCDG) are the gatekeepers of the tri-synaptic hippocamapal circuit in part by an intrinsically low cell excitability, which is pathologically increased in Temporal Lobe Epilepsy. ...