Now showing items 1-10 of 86
Nicotinic acetylcholine receptors at the single-channel level
(Wiley Blackwell Publishing, Inc, 2018-06)
Over the past four decades, the patch clamp technique and nicotinic ACh (nACh) receptors have established an enduring partnership. Like all good partnerships, each partner has proven significant in its own right, while ...
The nicotinic acetylcholine receptor as a molecular machine for neuromuscular transmission
The nicotinic acetylcholine receptor (nAChR) has crucial functions at the neuromuscular junction (NMJ). It belongs to the superfamily of pentameric ligand-gated ion channels and has become the stereotype for probing ...
Cardiovascular effects of transdermal nicotine in mildly hypertensive smokers
(Elsevier Science IncNew YorkEUA, 2001)
Effects of acetylcholine and cholinergic antagonists on the activity of nucleus of the solitary tract neurons
(Elsevier B.V., 2017-03-15)
Previously we have demonstrated that microinjection of acetylcholine (ACh) into the intermediate nucleus of the solitary tract (iNTS) induced sympatho-inhibition combined with a decrease in the phrenic nerve activity (PNA), ...
Molecular function of α7 nicotinic receptors as drug targets
(Wiley Blackwell Publishing, Inc, 2018-05-13)
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels involved in many physiological and pathological processes. In vertebrates, there are seventeen different nAChR subunits that combine to ...
A human-specific, truncated α7 nicotinic receptor subunit assembles with full-length α7 and forms functional receptors with different stoichiometries
(American Society for Biochemistry and Molecular Biology, 2018-05-21)
The cholinergic 7 nicotinic receptor gene, CHRNA7, encodes a subunit that forms the homopentameric 7 receptor, involved in learning and memory. In humans, exons 5–10 in CHRNA7 are duplicated and fused to the FAM7A genetic ...
Hemodynamic effects of a combination of bupropion and nicotine in anesthetized dogs
(Humana Press IncTotowaEUA, 2006)
Neurotransmitter GABA Activates Muscle but not a7 Nicotinic Receptors
(American Society For Pharmacology And Experimental Therapeutics, 2015-03)
Cys-loop receptors are neurotransmitter-activated ion channels involved in synaptic and extrasynaptic transmission in the brain and are also present in non-neuronal cells. As GABAA and nicotinic receptors (nAChR) belong ...
Molecular Determinants of Pyrantel Selectivity in Nicotinic Receptors
(American Society for Pharmacology and Experimental Therapeutics, 2006-12)
Nicotinic receptors (AChRs) play key roles in synaptic transmission throughout the nervous system. AChRs mediate neuromuscular transmission in nematodes and they are targets for antiparasitic drugs. The anthelmintic agents ...