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DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex
(Oxford University Press, 2019-01)
Cortical development is controlled by transcriptional programs, which are orchestrated by transcription factors. Yet, stable inheritance of spatiooral activity of factors influencing cell fate and localization in different ...
Interplay of environmental signals and progenitor diversity on fate specification of cortical GABAergic neurons
(2015-04-28)
Cortical GABAergic interneurons constitute an extremely diverse population of cells
organized in a well-defined topology of precisely interconnected cells. They play a
crucial role regulating inhibitory-excitatory balance ...
Ric-8B is important for neuronal differentiation of human Neuroblastoma SH-SY5Y cells.
(2014)
Neuronal differentiation starts in early stages of embryonic development. In this process,
neurons acquire a defined identity which is characterized by the position of neuronal body,
the pattern of axonal projections and ...
Single neuron coding of identity in the human hippocampal formation
(Cell Press, 2020-03-23)
Experimental findings show the ubiquitous presence of graded responses and tuning curves in the neocortex, particularly in visual areas [1–15]. Among these, inferotemporal-cortex (IT) neurons respond to complex visual ...
The homeodomain transcription factor NKX2.1 is essential for the early specification of melanocortin neuron identity and activates Pomc expression in the developing hypothalamus
(Society for Neuroscience, 2019-05)
Food intake is tightly regulated by a group of neurons present in the arcuate nucleus of the hypothalamus, which release Pomc-encoded melanocortins, the absence of which induces marked hyperphagia and early-onset obesity. ...
Neurogenin3 restricts serotonergic neuron differentiation to the hindbrain
(Society for Neuroscience, 2014-11)
The development of the nervous system is critically dependent on the production of functionally diverse neuronal cell types at their correct locations. In the embryonic neural tube, dorsoventral signaling has emerged as a ...
Neuronal Assembly Detection and Cell Membership Specification by Principal Component Analysis
(2011)
In 1949, Donald Hebb postulated that assemblies of synchronously activated neurons are the elementary units of
information processing in the brain. Despite being one of the most influential theories in neuroscience, Hebb’s ...
Specific Phospholipids Regulate the Acquisition of Neuronal and Astroglial Identities in Post-Mitotic Cells
(Nature Publishing Group, 2018-12)
Hitherto, the known mechanisms underpinning cell-fate specification act on neural progenitors, affecting their commitment to generate neuron or glial cells. Here, we show that particular phospholipids supplemented in the ...