article
Interplay of environmental signals and progenitor diversity on fate specification of cortical GABAergic neurons
Fecha
2015-04-28Registro en:
Brandão JA and Romcy-Pereira RN (2015) Interplay of environmental signals and progenitor diversity on fate specification of cortical GABAergic neurons. Front. Cell. Neurosci. 9:149. doi: 10.3389/fncel.2015.00149
1662-5102
Autor
Brandão, Juliana A.
Romcy-Pereira, Rodrigo Neves
Resumen
Cortical GABAergic interneurons constitute an extremely diverse population of cells
organized in a well-defined topology of precisely interconnected cells. They play a
crucial role regulating inhibitory-excitatory balance in brain circuits, gating sensory
perception, and regulating spike timing to brain oscillations during distinct behaviors.
Dysfunctions in the establishment of proper inhibitory circuits have been associated
to several brain disorders such as autism, epilepsy, and schizophrenia. In the rodent
adult cortex, inhibitory neurons are generated during the second gestational week from
distinct progenitor lineages located in restricted domains of the ventral telencephalon.
However, only recently, studies have revealed some of the mechanisms generating the
heterogeneity of neuronal subtypes and their modes of integration in brain networks.
Here we will discuss some the events involved in the production of cortical GABAergic
neuron diversity with focus on the interaction between intrinsically driven genetic
programs and environmental signals during development.