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Nucleophilic non-metal assited trifluoromethylation and perfluoroalkylation reactions of organic substrates
(Elsevier, 2014-01)
Nucleophilic trifluoromethylation and perfluoroalkylation reactions have been the outstanding approach during the last few decades to effect fluoroalkyl group addition or substitution reactions. In most instances, ...
New insights on reaction pathway selectivity promoted by crown ether phase-transfer catalysis: Model ab initio calculations of nucleophilic fluorination
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
Crown ethers have the ability of solubilizing inorganic salts in apolar solvents and to promote chemical reactions by phase-transfer catalysis. However, details on how crown ethers catalyze ionic S(N)2 reactions and control ...
Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates
(Elsevier, 2018)
Late Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical ...
Fluorination methods in drug discovery
(Royal Society Of Chemistry, 2016-05)
Fluorination reactions of medicinal and biologically-active compounds will be discussed. Late stage fluorination strategies of medicinal targets have recently attracted considerable attention on account of the influence ...
Mechanistic insights into the ANRORC-like rearrangement between methylhydrazine and 1,2,4-oxadiazole derivatives
(Royal Soc Chemistry, 2015)
We herein present the first in-depth theoretical study devoted to elucidate the mechanism of the
reaction between 1,2,4-oxadiazole derivatives and methylhydrazine. For this purpose, the
reaction between methylhydrazine ...
Changes in the SNAr reaction mechanism brought about by preferential solvation
(Royal Society of Chemistry, 2015)
We herein report an experimental and theoretical study on preferential solvation effects for the reactions of 1-fluoro and 1-chloro-2,4-dinitrobenzene towards morpholine in acetonitrile, water and mixtures of them of varying ...
Changes in the SNAr reaction mechanism brought about by preferential solvation
(Royal Society of Chemistry, 2015)
We herein report an experimental and theoretical study on preferential solvation effects for the reactions of 1-fluoro and 1-chloro-2,4-dinitrobenzene towards morpholine in acetonitrile, water and mixtures of them of varying ...
Recent Advances in Trifluoromethylation Reactions with Electrophilic Trifluoromethylating Reagents
(Wiley, 2014-10)
Electrophilic trifluoromethylation reactions have been the latest approach to achieve the fluoroalkylation of compounds with newly-discovered reagents, such as the Togni’s (1-trifluoromethyl-1,2-benziodoxol-3-(1 H)-one), ...
Meisenheimer complexes as hidden intermediates in the aza-SNAr mechanism
(Royal Society of Chemistry, 2020)
In this work we report a computational study about the aza-SNAr mechanism in fluorine- and chlorine-containing azines with the aim to unravel the physical factors that determine the reactivity patterns in these heterocycles ...