In contrast with the reductionist “one gene, one target, one drug” approach, network pharmacology proposes the use of multi-target therapies, a strategy that seems particularly suitable to treat disorders of complex etiology, ...

Tinnitus, the phantom perception of sound, is a prevalent disorder. One in 10 adults has clinically significant subjective tinnitus, and for 1 in 100, tinnitus severely affects their quality of life. Despite the significant ...

Network-pharmacology is a field of pharmacology emerging from the observation that most clinical drugs have multiple targets, contrasting with the previously dominant magic bullet paradigm which proposed the search of ...

Rhizoma Polygonati (huangjing in Chinese, 黄精) is an herb-homology-food used as a component of alternative medicine treating COVID-19 in the current pandemic emergency in China but the mechanisms remain elusive. Here using ...

Multi-target agents have attracted great attention in the last 15 years, as they are expected to provide more efficacious and safer therapeutic solutions, less prone to drug resistance phenomena. They thus seem particularly ...

Objective To analyze the lifetime trajectories in genetic generalized epilepsies (GGEs) and investigate the impact of symptoms of anxiety and depression on resting state functional connectivity (FC). Methods Seventy-four ...

hinese herbal formulas including the lung-cleaning and toxicity-excluding (LCTE) soup have played an important role in treating the ongoing COVID-19 pandemic (caused by SARS-CoV2) in China. Applying LCTE outside of China ...