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One-pot biosynthesis of idoxuridine using nanostabilized lactic acid bacteria
(Elsevier, 2017-11)
An efficient bioprocess using immobilized lactic acid bacteria to obtain 5-iodouracil-2′-deoxyriboside, known as idoxuridine, is reported. This nucleoside analogue is an antiviral agent used in the treatment of viral ...
Biotransformation of cladribine by a magnetic immobilizated biocatalyst of Lactobacillus animalis
(Springer, 2020-07)
A stable biocatalyst with magnetic properties based on immobilized Lactobacillus animalis ATCC 35,046 to obtain 2-chloroadenine-2′-deoxyriboside, known as cladribine, is reported for the first time. This nucleoside analogue ...
2′-Deoxyribosyltransferase from Leishmania mexicana, an efficient biocatalyst for one-pot, one-step synthesis of nucleosides from poorly soluble purine bases
(Applied Microbiology and Biotechnology, 2018)
Biotransformation of halogenated nucleosides by immobilized Lactobacillus animalis 2′- N -deoxyribosyltransferase
(Elsevier Science Sa, 2016-06)
An immobilized biocatalyst with 2′-N-deoxyribosyltransferase (NDT) activity, Lactobacillus animalis NDT (LaNDT), was developed from cell free extracts. LaNDT was purified, characterized and then immobilized by ionic ...
Development of a high efficient biocatalyst by oriented covalent immobilization of a novel recombinant 2′-N-deoxyribosyltransferase from Lactobacillus animalis
(Elsevier Science, 2018-03)
The 2′-N-deoxyribosyltransferases [NDT; EC 2.4.2.6] are a group of enzymes widely used as biocatalysts for nucleoside biosynthesis. In this work, the molecular cloning, expression and purification of a novel NDT from ...
Molecular basis of Ndt-mediated activation of nucleoside-based prodrugs and application in suicide gene therapy
(Corporación Universidad de la Costa, 2021)