This paper presents a new MILP mathematical formulation for the scheduling of resource-constrained multiproduct plants involving continuous processes. In such facilities, a sequence of continuous processing steps is usually ...

This contribution presents a new Constraint Programming (CP) formulation to address the optimal operation of multiproduct continuous processes. In particular, facilities having continuous stages, which manufacture intermediate ...

Significant benefits can be obtained if the interactions among different decision levels are appropriately addressed and simultaneously solved. In this work, a MILP formulation for the supply chain design is presented which ...

This work proposes a novel approach for the optimal design of multiproduct supply chain networks (SCN). Through a mixed integer linear programming (MILP) formulation the aim is to establish the structure of facilities that ...

In this work a biotechnological multiproduct batch plant that manufactures four different recombinant proteins for human application is described in some detail. This batch plant design is then optimized with regards ...

In recent years, many companies have shifted from single-site production to more complex manufacturing environments involving multiple multiproduct facilities. At the operational level, the scheduling posed on each individual ...

This work introduces a new MILP sequential approach to the short-term scheduling of multistage batch plants that accounts for sequence-dependent changeover times, intermediate due dates and limited availability of renewable ...

A mixed integer linear programming (MILP) for the detailed production planning of multiproduct batch plants is presented in this work. New timing decisions are incorporated to the model taking into account that an operation ...