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Antinociceptive effect of clomipramine in monoarthritic rats as revealed by the paw pressure test and the C-fiber-evoked reflex
(2001)
The antinociceptive effect of clomipramine was studied in monoarthritic rats by using the paw pressure test and the C-fiber-evoked reflex. Monoarthritis was produced by intra-articular injection of complete Freund's adjuvant ...
Interleukin-1β increases spinal cord wind-up activity in normal but not in monoarthritic rats
(Elsevier Ireland Ltd, 2003)
Cytokines produced by spinal cord glia after peripheral inflammation, infection or trauma have a relevant role in the maintenance of pain states. The effect of intrathecally administered interleukin-1β (IL-1β) on spinal ...
Expression of nitric oxide synthase isoforms in the dorsal horn of monoarthritic rats: effects of competitive and uncompetitive N-methyl-D-aspartate antagonists
(2007)
Chronic pain is associated with N-methyl-D-aspartate (NMDA) receptor activation and downstream production of nitric oxide, which has a pivotal role in multisynaptic local circuit nociceptive processing in the spinal cord. ...
Monoartrite induzida por adjuvante completo de Freund em ratos Holtzman e avaliação dos efeitos induzidos pelo tratamento crônico com tiamina ou riboflavina
(Universidade Federal de Minas GeraisUFMG, 2013-03-01)
Preclinical models of rheumatoid arthritis (RA) in rodents have been widely used to investigate the disease mechanisms and also to screen new drugs. Similarities with the human disease and predictive value for efficacy and ...