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Excitation-metabolism coupling: role of membrane depolarization on the mitochondrial function
(2016)
Depolarizing stimuli induce signaling pathways in muscle that have pleiotropic effects. Two new voltage-dependent phenomena, excitation-transcription and excitation-metabolism coupling (EMC), add to the canonical ...
Mitochondrial aquaporin-8 knockdown in human hepatoma HepG2 cells causes ROS-induced mitochondrial depolarization and loss of viability
(Elsevier Inc, 2012-10)
Human aquaporin-8 (AQP8) channels facilitate the diffusional transport of H2O2 across membranes. Since AQP8 is expressed in hepatic inner mitochondrial membranes, we studied whether mitochondrial AQP8 (mtAQP8) knockdown ...
Mitochondrial calcium increase induced by ryr1 and ip3r channel activation after membrane depolarization regulates skeletal muscle metabolism
(2018)
Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by ...
Mitochondrial calcium increase induced by RyR1 and IP3R channel activation after membrane depolarization regulates skeletal muscle metabolism
(Frontiers Media, 2018-06)
Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by ...
Elevation of resting mitochondrial membrane potential of neural cells by cyclosporin A, BAPTA-AM, and Bcl-2
(Amer Physiological SocBethesdaEUA, 2000)
Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease
(2013)
Abstract
Background
Mitochondrial impairment has been implicated in the pathogenesis of Huntington’s disease (HD). However, how mutant huntingtin impairs mitochondrial ...
Docosahexaenoic acid prevents apoptosis of retina photoreceptors by activating the ERK/MAPK pathway
(Wiley Blackwell Publishing, Inc, 2006-07-26)
Identifying the trophic factors for retina photoreceptors and the intracellular pathways activated to promote cell survival is crucial for treating retina neurodegenerative diseases. Docosahexaenoic acid (DHA), the major ...
Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging
(Springer/Plenum Publishers, 2016-01)
Alterations in mitochondrial bioenergetics have been associated with brain aging. In order to evaluate the susceptibility of brain cortex synaptosomes and non-synaptic mitochondria to aging-dependent dysfunction, male Swiss ...