Mitochondrial calcium increase induced by ryr1 and ip3r channel activation after membrane depolarization regulates skeletal muscle metabolism

Abstract

Aim: We hypothesize that both type-1 ryanodine receptor (RyR1) and IP3-receptor (IP3R) calcium channels are necessary for the mitochondrial Ca2+ increase caused by membrane depolarization induced by potassium (or by electrical stimulation) of single skel