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Ethanol downregulates N- acyl phosphatidylethanolamine-phospholipase D expression in BV2 microglial cells via epigenetic mechanisms
(Elsevier Science, 2016-09)
Excessive ethanol drinking has deleterious effects on the brain. However, the effects of alcohol on microglia, the main mediator of the brain´s innate immune response remain poorly understood. On the other hand, the ...
Microglial Priming in Infections and Its Risk to Neurodegenerative Diseases
(Frontiers Media, 2022)
Transferrin Enhances Microglial Phagocytic Capacity
(Humana Press, 2019-02)
Transferrin (Tf) is a glycoprotein playing a critical role in iron homeostasis and transport and distribution throughout the body and within tissues and cells. This molecule has been shown to accelerate the process of ...
Tau oligomers and fibrils induce activation of microglial cells
(IOS Press, 2013)
Neuroinflammation is a process related to the onset of several neurodegenerative disorders, including Alzheimer's disease (AD). Increasing sets of evidence support the major role of deregulation of the interaction patterns ...
Transforming growth factor-beta 1 produced by hippocampal cells modulates microglial reactivity in culture
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005)
Activated microglia produce superoxide anion (O-2(center dot-)) and nitric oxide (NO), both of which can be neurotoxic. To identify regulatory mechanisms that might modulate over-activation of microglia, we evaluated the ...
A simplified approach for efficient isolation of functional microglial cells: Application for modeling neuroinflammatory responses in vitro
(Wiley-liss, Div John Wiley & Sons Inc, 2016-11)
Purified microglial cells in culture are frequently used to model brain inflammatory responses but obtaining large yields of these cells on a routine basis can be quite challenging. Here, we demonstrate that it is possible ...