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Major histocompatibility complex (MHC) class II but not MHC class I molecules are required for efficient control of Strongyloides venezuelensis infection in mice
(WILEY-BLACKWELL PUBLISHING, INC, 2009)
P>Strongyloides stercoralis is an intestinal nematode capable of chronic, persistent infection and hyperinfection of the host; this can lead to dissemination, mainly in immunosuppressive states, in which the infection can ...
Contrasting patterns of selection between MHC I and II across populations of Humboldt and Magellanic penguins
(Wiley, 2016)
The evolutionary and adaptive potential of populations or species facing an emerging infectious disease depends on their genetic diversity in genes, such as the major histocompatibility complex (MHC). In birds, MHC class ...
Improved pan-specific MHC class I peptide-binding predictions using a novel representation of the MHC-binding cleft environment
(Wiley, 2014)
Major histocompatibility complex (MHC) molecules play a key role in cell-mediated immune responses presenting bounded peptides for recognition by the immune system cells. Several in silico Methods: have been developed to ...
Improved pan-specific MHC class I peptide binding predictions using a novel representation of the MHC binding cleft environment
(Wiley, 2014-02)
Major histocompatibility complex (MHC) molecules play a key role in cell-mediated immune responses presenting bounded peptides for recognition by the immune system cells. Several in silico methods have been developed to ...
NetTepi: an integrated method for the prediction of T-cell epitopes
(Springer Verlag Berlín, 2014-08)
Multiple factors determine the ability of a peptide to elicit a cytotoxic T cell lymphocyte response. Binding to a major histocompatibility complex class I (MHC-I) molecule is one of the most essential factors, as no peptide ...
MHC class I and II expression in juvenile dermatomyositis skeletal muscle
(CLINICAL & EXPER RHEUMATOLOGY, 2009)
Objective To assess MHC I and II expressions in muscle fibres of juvenile dermatomyositis (JDM) and compare with the expression in polymyositis (PM), dermatomyositis (DM) and dystrophy. Patients and methods Forty-eight JDM ...
Improved pan-specific prediction of MHC class I peptide binding using a novel receptor clustering data partitioning strategy
(Wiley Blackwell Publishing, Inc, 2016-12)
Pan-specific prediction of receptor–ligand interaction is conventionally done using machine-learning methods that integrates information about both receptor and ligand primary sequences. To achieve optimal performance using ...
Caracterización molecular y análisis evolutivo del complejo mayor de histocompatibilidad clase I (MHC-I) en primates del nuevo mundo (Platyrrhini)
(2014)
El complejo mayor de histocompatibilidad clase I (MHC-I) codifica para proteínas de membrana que presentan péptidos antigénicos a los linfocitos T citotóxicos que inician la respuesta inmune celular [1]. El MHC-I se ha ...
Gapped sequence alignment using artificial neural networks: Application to the MHC class I system
(Oxford University Press, 2016-02-15)
Motivation: Many biological processes are guided by receptor interactions with linear ligands of variable length. One such receptor is the MHC class I molecule. The length preferences vary depending on the MHC allele, but ...