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Raf/MEK/ERK pathway activation is required for Junín virus replication
(Society for General Microbiology, 2014)
Polymorphisms in RAS/RAF/MEK/ERK pathway are associated with gastric cancer
(MDPI AG, 2019)
The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers ...
Análise da influência dos inibidores farmacológicos das vias celulares de MEK/ERK, JNK e PI3K/AKT no ciclo de replicação do vírus da febre amarela
(Universidade Federal de Minas GeraisUFMG, 2011-02-22)
During the process of co-evolution with their hosts, the viruses acquired the capacity of intercept, mimic and usurp several cellular signaling pathways in a way to generate favorable conditions to the replication and ...
Participación de las vías de señalización celular dependientes de proteínas quinasas activadas por mitógenos Raf/MEK/ERK y p38 en la multiplicación del virus JunínInvolvement of mitogen-activated protein kinase - dependent signaling pathways Raf/MEK/ERK and p38 in Junín virus multiplication
(2019-03-12)
El virus Junín (JUNV), miembro de la familia Arenaviridae, es el agente causal de la fiebre hemorrágica argentina, enfermedad endemo-epidémica que afecta una amplia zona central de la República Argentina y para la cual, ...
Hormonal activation of a kinase cascade localized at the mitochondria is required for StAR protein activity
(Elsevier Ireland, 2009-12)
It is known that ERK1/2 and MEK1/2 participate in the regulation of Star gene transcription. However, their role in StAR protein post-transcriptional regulation is not described yet. In this study we analyzed the relationship ...
Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer
(2019)
The RAS/RAF/MEK/ERK pathway regulates certain cellular functions, including cell proliferation, differentiation, survival, and apoptosis. Dysregulation of this pathway leads to the occurrence and progression of cancers ...
Análise morfológica do ciclo de multiplicação do Chikungunya vírus e avaliação do potencial antiviral do inibidor de MEK/ERK Trametinibe (Mekinist)
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE MICROBIOLOGIAPrograma de Pós-Graduação em MicrobiologiaUFMG, 2020-12-21)
The chikungunya virus (CHIKV) is an enveloped virus with an RNA positive
strand genome, transmitted between sperm vertebrates and arthropod vectors such
as Aedes aegypti and Aedes albopictus, comprising three genotypes. ...
The adipokine chemerin augments vascular reactivity to contractile stimuli via activation of the MEK-ERK1/2 pathway
(PERGAMON-ELSEVIER SCIENCE LTDOXFORD, 2012)
Aims: Cytokines interfere with signaling pathways and mediators of vascular contraction. Endothelin-1 (ET-1) plays a major role on vascular dysfunction in conditions characterized by increased circulating levels of adipokines. ...
Oligodendrocyte differentiation and signaling after transferrin internalization: a mechanism of action
(Elsevier, 2013-10)
Oligodendrocytes are the cells producing the myelin membrane around the axons in the central nervous system and, although apotransferrin (aTf) is required for oligodendrocyte differentiation, the underlying mechanisms are ...