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Antigen processing and presentation
(Elsevier Inc, 2019-01)
Dendritic cells are at the center of immune responses. They are defined by their ability to sense the environment, take up and process antigen, migrate to secondary lymphoid organs, where they present antigens to the ...
NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data
(Oxford University Press, 2020-07)
Major histocompatibility complex (MHC) molecules are expressed on the cell surface, where they present peptides to T cells, which gives them a key role in the development of T-cell immune responses. MHC molecules come in ...
Footprints of antigen processing boost MHC class II natural ligand predictions
(Springer Nature, 2018-11)
BACKGROUND: Major histocompatibility complex class II (MHC-II) molecules present peptide fragments to T cells for immune recognition. Current predictors for peptide to MHC-II binding are trained on binding affinity data, ...
Improved Prediction of MHC II Antigen Presentation through Integration and Motif Deconvolution of Mass Spectrometry MHC Eluted Ligand Data
(American Chemical Society, 2020-06)
Major histocompatibility complex II (MHC II) molecules play a vital role in the onset and control of cellular immunity. In a highly selective process, MHC II presents peptides derived from exogenous antigens on the surface ...
Improved peptide-MHC class II interaction prediction through integration of eluted ligand and peptide affinity data
(Springer, 2019-05)
Major histocompatibility complex (MHC) class II antigen presentation is a key component in eliciting a CD4+ T cell response. Precise prediction of peptide-MHC (pMHC) interactions has thus become a cornerstone in defining ...
Antigen presentation unfolded: identifying convergence points between the UPR and antigen presentation pathways
(Elsevier, 2018-06)
The unfolded protein response (UPR) is an adaptive response meant to restore endoplasmic reticulum homeostasis in conditions of ER stress that subvert the folding capacity of the cell. Over the past few years, it has become ...
Accurate pan-specific prediction of peptide-MHC class II binding affinity with improved binding core identification
(Springer, 2015-09)
A key event in the generation of a cellular response against malicious organisms through the endocytic pathway is binding of peptidic antigens by major histocompatibility complex class II (MHC class II) molecules. The bound ...
Chlamydia trachomatis Infection Impairs MHC-I Intracellular Trafficking and Antigen Cross-Presentation by Dendritic Cells
(Frontiers Media, 2021-04)
During cross-presentation, exogenous antigens (i.e. intracellular pathogens or tumor cells) are internalized and processed within the endocytic system and also by the proteasome in the cytosol. Then, antigenic peptides are ...
Immune complexes (IC) down-regulate the basal and interferon-γ-induced expression of MHC class II on human monocytes
(Wiley Blackwell Publishing, Inc, 2001-08)
The interaction of Fc receptors for IgG (FcγRs) on monocytes/macrophages with immune complexes (IC) triggers regulatory and effector functions. Previous studies have shown that FcγR-IC interactions inhibit the IFN-γ-induced ...