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SARS-CoV fusion peptides induce membrane surface ordering and curvature
(2016-11-28)
Viral membrane fusion is an orchestrated process triggered by membrane-anchored viral fusion glycoproteins. The S2 subunit of the spike glycoprotein from severe acute respiratory syndrome (SARS) coronavirus (CoV) contains ...
Wrinkles and splay conspire to give positive disclinations negative curvature
(National Academy of Sciences, 2015-10)
Recently, there has been renewed interest in the coupling between geometry and topological defects in crystalline and striped systems. Standard lore dictates that positive disclinations are associated with positive Gaussian ...
Order-disorder skewness in alpha-synuclein: A key mechanism to recognize membrane curvature
(Royal Society of Chemistry, 2020-03)
Currently, membrane curvature is understood as an active mechanism to control cells spatial organization and activity. Protein processes involved in sensing and generating curvature are therefore of major interest. In this ...
Arf1 and membrane curvature cooperate to recruit Arfaptin2 to liposomes
(PUBLIC LIBRARY SCIENCE, 2013-04-29)
Arfaptin2 contains a Bin/Amphiphysin/Rvs (BAR) domain and directly interacts with proteins of the Arf/Arl family in their active GTP-bound state. It has been proposed that BAR domains are able to sense membrane ...
Miltefosine inhibits the membrane remodeling caused by phospholipase action by changing membrane physical properties
(Elsevier Science, 2020-10)
Miltefosine (hexadecylphosphocholine or HePC) is an alkylphosphocholine approved for the treatment of visceral and cutaneous Leishmaniasis. HePC exerts its effect by interacting with lipid membranes and affecting ...
Conformational changes, from β-strand to α-helix, of the fatty acid-binding protein ReP1-NCXSQ in anionic lipid membranes: dependence with the vesicle curvature
(Springer, 2017-07)
We studied the conformational changes of the fatty acid-binding protein ReP1-NCXSQ in the interface of anionic lipid membranes. ReP1-NCXSQ is an acidic protein that regulates the activity of the Na+/Ca2+ exchanger in squid ...
Measuring the composition-curvature coupling in binary lipid membranes by computer simulations
(American Institute of Physics, 2014-11)
The coupling between local composition fluctuations in binary lipid membranes and curvatureaffects the lateral membrane structure. We propose an efficient method to compute the composition-curvature coupling in molecular ...
Detecting phospholipase activity with the amphipathic lipid packing sensor motif of ArfGAP1
(Academic Press Inc Elsevier Science, 2018-10)
The amphipathic lipid packing sensor (ALPS) motif of ArfGAP1 brings this GTPase activating protein to membranes of high curvature. Phospholipases are phospholipid-hydrolyzing enzymes that generate different lipid products ...