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MAPKs and signal transduction in the control of gastrointestinal epithelial cell proliferation and differentiation
(MDPIBasel, 2013-05-13)
Mitogen-activated protein kinase (MAPK) pathways are activated by several stimuli and transduce the signal inside cells, generating diverse responses including cell proliferation, differentiation, migration and apoptosis. ...
Proliferative cells in racemose neurocysticercosis have an active MAPK signalling pathway and respond to metformin treatment
(Elsevier, 2022)
Racemose neurocysticercosis is an aggressive infection caused by the aberrant expansion of the cyst form of Taenia solium within the subarachnoid spaces of the human brain and spinal cord, resulting in the displacement of ...
O papel da via de sinalização p38 MAPK no desenvolvimento do Schistosoma mansoni (Platyhelminthes:Trematoda) e na proteção contra o estresse oxidativo
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOLOGIA GERALPrograma de Pós-Graduação em GenéticaUFMG, 2013-08-30)
There are three important Schistosoma species parasitizing humans: Schistosoma
mansoni, S. japonicum and S. haematobium. Together, they are responsible for the chronic
infection of 200 million people and over 200,000 ...
Systematic review of p38 mitogen-activated kinase and its functional role in reproductive tissues
(2018-01-01)
Oxidative stress (OS) plays a role in uterine tissue remodeling during pregnancy and parturition. While p38 MAPK is an OS-response kinase, a precise functional role is unknown. Therefore, we conducted a systematic review ...
Lack of association between BRAF mutation and MAPK ERK activation in melanocytic nevi
(NATURE PUBLISHING GROUP, 2006)
The mitogen-activated protein kinase (MAPK) extracellular signal-regulated kinase signaling pathway can be activated through mutations of V-RAF murine sarcoma viral oncogene homolog B1 (BRAF) oncogene, frequently found in ...
MAPK7 Gene Controls Proliferation, Migration and Cell Invasion in Osteosarcoma
(Wiley-Blackwell, 2016)
Osteosarcomas (OS) are the most common malignant bone tumors, and the identification of useful tumor biomarkers and target proteins is required to predict the clinical outcome of patients and therapeutic response as well ...
Role of estrogen receptors, PKC and Src in ERK2 and p38 MAPK signaling triggered by 17β-estradiol in skeletal muscle cells
(Pergamon-Elsevier Science Ltd, 2010-10)
We have previously reported in C2C12 murine skeletal muscle cells that 10-8M 17β-estradiol promotes MAPKs stimulation which in turn mediates the activation of CREB and Elk-1 transcription factors. In this work, we demonstrated ...
MAPK pathways regulation by DUSP1 in the development of osteosarcoma: Potential markers and therapeutic targets
(Wiley, 2017)
Osteosarcoma (OS) is the most frequent primary bone tumor that affect children and adolescents. This tumor is highly aggressive with high risk of metastasis and the implementation of new drugs has not been successful. The ...
Dissection of MAPK signaling specificity through protein engineering in a developmental context
(BioMed Central, 2018-04)
Background: Mitogen-activated protein kinases (MAPK) signaling affects many processes, some of which have different outcomes in the same cell. In Arabidopsis, activation of a MAPK cascade consisting of YODA, MKK4/5 and ...
Intrinsic Feedbacks in MAPK Signaling Cascades Lead to Bistability and Oscillations
(Springer, 2013-02)
Previous studies have demonstrated that double phosphorylation of a protein can lead to bistability if some conditions are fulfilled. It was also shown that the signaling behavior of a covalent modification cycle can be ...