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MAPKs and signal transduction in the control of gastrointestinal epithelial cell proliferation and differentiation
(MDPIBasel, 2013-05-13)
Mitogen-activated protein kinase (MAPK) pathways are activated by several stimuli and transduce the signal inside cells, generating diverse responses including cell proliferation, differentiation, migration and apoptosis. ...
Signaling cascades transmit information downstream and upstream but unlikely simultaneously
(BioMed Central, 2016-08)
Background: Signal transduction is the process through which cells communicate with the external environment, interpret stimuli and respond to them. This mechanism is controlled by signaling cascades, which play the role ...
Intrinsic Feedbacks in MAPK Signaling Cascades Lead to Bistability and Oscillations
(Springer, 2013-02)
Previous studies have demonstrated that double phosphorylation of a protein can lead to bistability if some conditions are fulfilled. It was also shown that the signaling behavior of a covalent modification cycle can be ...
PTH regulation of c-Jun Terminal Kinase and p38 MAPK Cascades in cells from young and aged rats
(Springer, 2007-12)
In the present study, we examined the role of Parathyroid hormone (PTH) on the c-Jun N-terminal kinase (JNK) 1/2 and p38 mitogen- activated protein kinase (MAPK) members of the MAPK family as it relates to ageing by measuring ...
Estudo funcional do gene mapk7, proposto como marcador prognóstico em osteosarcoma
(Universidade Federal de São Paulo (UNIFESP), 2014-05-29)
Osteosarcomas (OS) are the most common malignant bone tumors, and the identification of useful tumor biomarkers and target proteins is required to predict the clinical outcome of patients and therapeutic response as well ...
MAPK7 Gene Controls Proliferation, Migration and Cell Invasion in Osteosarcoma
(Wiley-Blackwell, 2016)
Osteosarcomas (OS) are the most common malignant bone tumors, and the identification of useful tumor biomarkers and target proteins is required to predict the clinical outcome of patients and therapeutic response as well ...
Extracellular ATP activates MAP kinase cascades through a P2Y purinergic receptor in the human intestinal Caco-2 cell line
(Elsevier, 2009-10)
Background: ATP exerts diverse effects on various cell types via speci fi c purinergic P2Y receptors. Intracellular signaling cascades are the main routes of communication between P2Y receptors and regulatory targets in ...
Dissection of MAPK signaling specificity through protein engineering in a developmental context
(BioMed Central, 2018-04)
Background: Mitogen-activated protein kinases (MAPK) signaling affects many processes, some of which have different outcomes in the same cell. In Arabidopsis, activation of a MAPK cascade consisting of YODA, MKK4/5 and ...
Identifiability from a few species for a class of biochemical reaction networks
(Springer, 2019-07)
Under mass-action kinetics, biochemical reaction networks give rise to polynomial autonomous dynamical systems whose parameters are often difficult to estimate. We deal in this paper with the problem of identifying the ...
MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma
(Lippincott, Williams & Wilkins, 2017)