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Recent advances in the molecular beacon technology for live-cell single-molecule imaging
Nucleic acids, aside from being best known as the carrier of genetic information,
are versatile biomaterials for constructing nanoscopic devices for biointerfacing,
owing to their unique properties such as specific ...
Quantifying transcription factor binding dynamics at the single-molecule level in live cells
(Academic Press Inc Elsevier Science, 2017-07)
Progressive, technological achievements in the quantitative fluorescence microscopy field are allowing researches from many different areas to start unraveling the dynamic intricacies of biological processes inside living ...
Single-molecule analysis of steroid receptor and cofactor action in living cells
(Nature Publishing Group, 2017-06-21)
Population-based assays have been employed extensively to investigate the interactions of transcription factors (TFs) with chromatin and are often interpreted in terms of static and sequential binding. However, fluorescence ...
Single-molecule localization super-resolution microscopy of synaptic proteins
(Humana Press, 2022)
Application of artificial intelligence strategies to the analysis of neurotransmitter receptor dynamics in living cells
(Cambridge University Press, 2020)
Abstract: Storm (stochastical optical reconstruction microscopy), a form of single-molecule nanoscopy,
calls for a variety of statistical and mathematical operations to reconstruct the original objects from
their noisy ...
Nanometer resolution imaging and tracking of fluorescent molecules with minimal photon fluxes
(American Association for the Advancement of Science, 2017-02)
We introduce MINFLUX, a concept for localizing photon emitters in space. By probing the emitter with a local intensity minimum of excitation light, MINFLUX minimizes the fluorescence photons needed for high localization ...
Predicting Cancer Chemosensitivity Based on Intensity/Distribution Profiles of Cells Loaded with a Fluorescent Sphingolipid Analogue
(2018)
Cancer is a group of heterogeneous and complex
diseases, with limited therapeutic options due to the recurrent
emergence of drug resistance. Sphingolipids are bioactive
molecules that participate in signaling of cell ...