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Fatty acid regulation of voltage- and ligand-gated ion channel function
(Frontiers Research Foundation, 2016-11-28)
Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the physicochemical ...
Marine Toxins Targeting Ion Channels
(Molecular Diversity Preservation International, 2006-04)
This introductory minireview points out the importance of ion channels for cell communication. The basic concepts on the structure and function of ion channels triggered by membrane voltage changes, the so-called voltage-gated ...
Phylogenetic conservation of protein-lipid motifs in pentameric ligand-gated ion channels
(Elsevier Science, 2015-07)
Using the crosstalk between the nicotinic acetylcholine receptor (nAChR) and its lipid microenvironment as a paradigm, this short overview analyzes the occurrence of structural motifs which appear not only to be conserved ...
A change in the ion selectivity of ligand-gated ion channels provides a mechanism to switch behavior.
(Public Library Of Science, 2015-09)
Behavioral output of neural networks depends on a delicate balance between excitatory and inhibitory synaptic connections. However, it is not known whether network formation and stability is constrained by the sign of ...
Orthosteric and Allosteric Activation of Human 5-HT3A Receptors
(Cell Press, 2020-10-20)
The serotonin type 3 receptor (5-HT 3) is a ligand-gated ion channel that converts the binding of the neurotransmitter serotonin (5-HT) into a transient cation current that mediates fast excitatory responses in peripheral ...
Voltage-controlled gating in a large conductance Ca2+-sensitive K(+)channel (hslo)
(NATL ACAD SCIENCES, 1997-05-13)
Large conductance calcium- and voltage-sensitive K+ (MaxiK) channels share properties of voltage- and ligand-gated ion channels. In voltage-gated channels, membrane depolarization promotes the displacement of charged ...
Fatty acid regulation of voltage-and-ligand-gated ion channel function
(Frontiers, 2016)
Abstract: Free fatty acids (FFA) are essential components of the cell, where they play a key role in lipid and carbohydrate metabolism, and most particularly in cell membranes, where they are central actors in shaping the ...
Phylogenetic conservation of protein–lipid motifs in pentameric ligand-gated ion channels
(Elsevier B.V., 2015)
Abstract: Using the crosstalk between the nicotinic acetylcholine receptor (nAChR) and its lipid microenvironment as a
paradigm, this short overviewanalyzes the occurrence of structuralmotifswhich appear not only to be ...