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The Impact of Heterozygous KCNK3 Mutations Associated With Pulmonary Arterial Hypertension on Channel Function and Pharmacological Recovery
(Wiley, 2017)
Background-Heterozygous loss of function mutations in the KCNK3 gene cause hereditary pulmonary arterial hypertension (PAH). KCNK3 encodes an acid-sensitive potassium channel, which contributes to the resting potential of ...
Gating of two-pore domain K+ channels by extracellular pH
(Portland Press on behalf of The Biochemical Society, 2008)
Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear
(Elsevier, 2003)
K+ channels in the inner ear regulate the secretion and homeostasis of K+, i.e. the flux of K+ ions required to ensure good mechanosensory transduction. We studied the expression and cellular localization of TWIK-1 and ...
Homology and Pharmacophore Modeling, High Throughput Virtual Screening and Molecular Docking Studies to Iden!fy Poten!al Inhibitors of the Two-pore-Domain Potassium Channel K2P9.1 (TASK-3)
(2017)
Two-pore domain potassium channels (K2P) give rise to leak potassium currents, which control the excitability of the
cells. The human genome contains 15 KCNK genes coding for proteins able to form K2P channels subdivided ...