Buscar
Mostrando ítems 1-10 de 122
Phoenix Is Required for Mechanosensory Hair Cell Regeneration in the Zebrafish Lateral Line
(PUBLIC LIBRARY SCIENCE, 2009-04-17)
In humans, the absence or irreversible loss of hair cells, the sensory mechanoreceptors in the cochlea, accounts for a large
majority of acquired and congenital hearing disorders. In the auditory and vestibular neuroepithelia ...
Whole cell patch clamp recording of mouse and rat inner hair cells in the intact organ of Corti
(Springer, 2016)
Whole cell patch clamping is a widely applied method to record currents across the entire membrane of a cell. This protocol describes application of this method to record currents from the sensory inner hair cells in the ...
Spectrin βV adaptive mutations and changes in subcellular location correlate with emergence of hair cell electromotility in mammalians
(National Academy of Sciences, 2017-02)
The remarkable hearing capacities of mammals arise from various evolutionary innovations. These include the cochlear outer hair cells and their singular feature, somatic electromotility, i.e., the ability of their cylindrical ...
Inner hair cell and neuron degeneration contribute to hearing loss in a DFNA2-like mouse model
(Wiley, 2019)
DFNA2 is a progressive deafness caused by mutations in thevoltage-activated potassium channel KCNQ4. Hearing loss developswith age from a mild increase in hearing threshold to profounddeafness. The first phase starts around ...
Inner Hair Cell and Neuron Degeneration Contribute to Hearing Loss in a DFNA2-Like Mouse Model
(Pergamon-Elsevier Science Ltd, 2019-07-01)
DFNA2 is a progressive deafness caused by mutations in the voltage-activated potassium channel KCNQ4. Hearing loss develops with age from a mild increase in the hearing threshold to profound deafness. Studies using transgenic ...
Acute copper exposure induces oxidative stress and cell death in lateral line hair cells of zebrafish larvae
(ELSEVIER SCIENCE BV, 2008-12-09)
Numerous physical and chemical agents can destroy mechanosensory hair cells in the inner
ear of vertebrates, a process that is irreversible in mammals. Few experimental systems
allow the observation of hair cell death ...
Selective Inner Hair Cell Loss in Prematurity: A Temporal Bone Study of Infants from a Neonatal Intensive Care Unit
(SPRINGER, 2011)
Premature birth is a well-known risk factor for sensorineural hearing loss in general and auditory neuropathy in particular. However, relatively little is known about the underlying causes, in part because there are so few ...
Sub-lethal concentrations of waterborne copper are toxic to lateral line neuromasts in zebrafish (Danio rerio)
(ELSEVIER, 2006-03)
In teleosts, the lateral line system is composed of neuromasts containing hair cells that are analogous to those present in the inner ear
of all vertebrates. In the zebrafish embryo and early larva, this system is composed ...
Changes In The Inner Ear Structures In Cystic Fibrosis Patients
(Elsevier Ireland LTDClare, 2017)
Postsynaptic recordings at afferent dendrites contacting cochlear inner hair cells: Monitoring multivesicular release at a ribbon synapse
(Journal of Visualized Experiments, 2011-02)
The afferent synapse between the inner hair cell (IHC) and the auditory nerve fiber provides an electrophysiologically accessible site for recording the postsynaptic activity of a single ribbon synapse. Ribbon synapses of ...