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Hepatitis C virus in vitro replication is efficiently inhibited by acridone Fac4

Universidade Estadual Paulista (Unesp); Universidade Federal de Uberlândia (UFU); University of Leeds (2017-07-01)

Hepatitis C virus (HCV) affects about 170 million people worldwide. The current treatment has a high cost and variable response rates according to the virus genotype. Acridones, a group of compounds extracted from natural ...

Inhibition of hepatitis C virus using siRNA targeted to the virus and Hsp90

Universidade Estadual Paulista (Unesp); Mato Grosso Federal University (2017-01-01)

Hepatitis C (HCV) is a viral disease affecting millions of people worldwide, and persistent HCV infection can lead to progressive liver disease with the development of liver cirrhosis and hepatocellular carcinoma. During ...

Inhibition Of Avian Metapneumovirus (ampv) Replication By Rna Interference Targeting Nucleoprotein Gene (n) In Cultured Cells.

Ferreira, Helena Lage; Spilki, Fernando Rosado; de Almeida, Renata Servan; Santos, Márcia M A B; Arns, Clarice Weis (2007)

Antiviral activity of phosphonoformate on rotavirus transcription and replication

Ríos, Maritza; Muñoz, Marianne; Spencer, Eugenio (1995)

The antiviral effect of foscarnet (PFA) on the replication of rotavirus, a member of the Reoviridae, was studied. The pyrophosphate analogue is an effective inhibitor of several viral polymerases acting on the enzyme ...

Quinic acid derivatives inhibit dengue virus replication in vitro

Zanello, Paula Rodrigues; Koishi, Andrea Cristine; Rezende Júnior, Celso de Oliveira; Oliveira, Larissa Albuquerque; Pereira, Adriane Antonia; Almeida, Mauro Vieira de; Santos, Claudia Nunes Duarte dos; Bordignon, Juliano (BioMed Central, 2017)

Novel inhibitors of the main protease enzyme of SARS-CoV-2 identified via molecular dynamics simulation-guided in vitro assay

Institute of Biological Information Processing: Structural Biochemistry (IBI-7); Heinrich Heine University Düsseldorf; Universidade Estadual Paulista (Unesp); Obafemi Awolowo University (2021-06-01)

For the COVID-19 pandemic caused by SARS-CoV-2, there are currently no effective drugs or vaccines to treat this coronavirus infection. In this study, we focus on the main protease enzyme of SARS-CoV-2, 3CLpro, which is ...

DISTRIBUCIÓN INTRACELULAR DE LA PROTEASA VIRAL 3CD DEL FCV DURANTE LA INFECCIÓN

M. en C. LONCHES CLOTILDE, CANCIO (2011-06-06)

Acute gastroenteritis is an important health problem with high mobility and mortality rates in the entire world. It is caused by several pathogens, such as viruses. Among them, the members of the Caliciviridae family, that ...

Potential therapeutic agents against COVID-19 based on blocking and inhibition of the viral life cycle and the cytokine storm syndrome

Pastrian Soto,Gabriel (EFACIM. Editorial de la Facultad de Ciencias Médicas - Universidad Nacional de Asunción, 2020)

CRISPR / Cas-9 Vector System: Targets UL-39 and Inhibits HSV-1 Replication in Vitro

Raposo, Jéssica Vasques; Barros, Luciana Rodrigues Carvalho; Torres, Lauana Ribas; Pinto, Rafaela Barbosa da Silva; Lopes, Amanda de Oliveira; Souza, Elen Mello de; Bonamino, Martin Hernan; Paula, Vanessa Salete de (Research Square, 2023)

N-6 -methyladenosine negatively regulates human respiratory syncytial virus replication

Figueroa, Fabián; Vega Gibson, Alonso Gonzalo; Catrileo, Joseline; Gaete Argel, Aracelly Janis; Riquelme Barrios, Sebastián Andrés; Alonso Palomares, Luis Antonio; Tapia Faúndes, Lorena; Valiente Echeverría, Fernando Andrés; Soto Rifo, Ricardo Andrés; Acevedo Acevedo, Mónica Loreto (Frontiers Media, 2021)

N 6 -methyladenosine (m6A) is the most abundant internal modification described in eukaryotic mRNA and several viral RNA including human respiratory syncytial virus (HRSV). Here, we evaluated the impact of m6A writers, ...

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