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Enantioselective analysis of oxybutynin and N-desethyloxybutynin with application to an in vitro biotransformation study
(ELSEVIER SCIENCE BV, 2008)
An enantioselective method using liquid-phase microextraction (LPME) followed by HPLC analysis was developed for the determination of oxybutynin (OXY) and its major metabolite N-desethyloxybutynin (DEO) in rat liver ...
Chiral HPLC analysis of venlafaxine metabolites in rat liver microsomal preparations after LPME extraction and application to an in vitro biotransformation study
(SPRINGER HEIDELBERG, 2010)
A three-phase LPME (liquid-phase microextraction) method for the enantioselective analysis of venlafaxine (VF) metabolites (O-desmethylvenlafaxine (ODV) and N-desmethylvenlafaxine (NDV) in microsomal preparations is described ...
Hollow fiber-based liquid-phase microextraction (HF-LPME) of isradipine and its main metabolite followed by chiral HPLC analysis: application to an in vitro biotransformation study
(SPRINGER HEIDELBERG, 2011)
An enantioselective liquid chromatographic method using two-phase hollow fiber liquid-phase microextraction (HF-LPME-HPLC) was developed for the determination of isradipine (ISR) enantiomers and its main metabolite (pyridine ...
Identification of biotransformation products of disperse dyes with rat liver microsomes by LC-MS/MS and theoretical studies with DNA: Structure-mutagenicity relationship using Salmonella/microsome assay
(2018-02-01)
Azo dyes are known as a group of substances with DNA damage potential that depend on the nature and number of azo groups connected to aromatic rings (benzene and naphthalene), chemical properties, e.g. solubility and ...
Comparative xenobiotic biotransformation in precission-cut liver slices from swine and cattle
(Medicina (Buenos Aires), 2019)
Species differences in the pattern of metabolism of foreign compounds is a key issue for veterinary practitioners. Comparative studies on the in vitro hepatic metabolism of xenobiotics among different farm animals requires ...
Cytotoxic, biochemical and genotoxic effects of biodiesel produced by different routes on ZFL cell line
(Elsevier B.V., 2014-09-01)
Transesterification has proved to be the best option for obtaining biodiesel and, depending on the type of alcohol used in the reaction, the type of biodiesel may be methyl ester or ethyl ester. Leaking biodiesel can reach ...
Improving the chemopreventive potential of orange juice by enzymatic biotransformation
(Elsevier Science BvAmsterdamHolanda, 2013)
Biotransformation of disperse dyes using nitroreductase immobilized on magnetic particles modified with tosyl group: Identification of products by LC-MS-MS and theoretical studies conducted with DNA
(2018-11-01)
The present work evaluates the action of nitroreductase enzyme immobilized on Tosylactivated magnetic particles (MP-Tosyl) on three disperse dyes which contain nitro and azo groups. The dyes included Disperse Red 73 (DR ...
Rat liver microsomal and nuclear activation of methanol to hydroxymethyl free radicals
(Elsevier Ireland, 2002-03)
Recent studies from other laboratories reported that during methanol intoxication lipid peroxidation and protein oxidation in liver occurred. Further, they detected free radicals-PBN adducts in bile and urine of methanol ...
Analyses of the genotoxic and mutagenic potential of the products formed after the biotransformation of the azo dye Disperse Red 1
(Pergamon-Elsevier B.V. Ltd, 2011-12-01)
Azo dyes constitute the largest class of synthetic dyes. Following oral exposure, these dyes can be reduced to aromatic amines by the intestinal microflora or liver enzymes. This work identified the products formed after ...