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Dual IRE1 RNase functions dictate glioblastoma development
(Wiley, 2018)
Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical ...
The UPRosome-decoding novel biological outputs of IRE1 alpha function
(Company Biologists, 2020)
Different perturbations alter the function of the endoplasmic reticulum (ER), resulting in the accumulation of misfolded proteins in its lumen, a condition termed ER stress. To restore ER proteostasis, a highly conserved ...
Role of collagen chaperone HSP47 on the activation of endoplasmic reticulum stress sensor IRE1α
(Universidad de Chile, 2018)
Alteraciones en la homeostasis del retículo endoplasmático (RE) promueven la acumulación de proteínas mal plegadas en su lumen, una condición celular denominada estrés de RE. La adaptación al estrés de RE depende de la ...
A Amara IréA Amara IréA Amara Iré
(Universidad de Puerto Rico, Recinto de Río Piedras, 2023)
IRE1 controls cytoskeleton remodeling and cell migration as a scaffold that binds Filamin A
(2017)
IRE1α is crucial signal transducer of the unfolded protein response (UPR). Classical activation of IRE1α under
ER stress triggers adaptive and pro-apoptotic signals; however, recent reports have suggested new functions
of ...
Non-canonical function of IRE1 alpha determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics
(2019)
Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the mitochondrial matrix. Here, we report an unexpected ...
IRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A
(2018)
Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer ...
IRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A
(2018)
Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer ...
Human cDC1s display constitutive activation of the UPRsensor IRE1
(Wiley, 2022)
The intracellular mechanisms safeguarding DC function are of biomedical interest in several immune-related diseases. Type 1 conventional DCs (cDC1s) are prominent targets of immunotherapy typified by constitutive activation ...
Regulación de la funcionalidad de las células dendríticas en el tracto intestinal a través de la activación del sensor IRE1
(Universidad de Chile, 2021)
El sistema inmune intestinal está constituido por diferentes tipos celulares, que actúan
de manera coordinada para controlar finamente la inmunidad y tolerancia.
Perturbaciones en este equilibrio entre inmunidad y ...