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Intratumor heterogeneity index of breast carcinomas based on DNA methylation profiles
(BioMed Central, 2019-04)
Background: Cancer cells evolve and constitute heterogeneous populations that fluctuate in space and time and are subjected to selection generating intratumor heterogeneity. This phenomenon is determined by the acquisition ...
Avaliação da heterogeneidade intratumoral e intermetástases do éxon 15 do gene braf (7q34) em amostras de melanoma metastático
(Universidade Federal de São Paulo (UNIFESP), 2015-06-05)
Introduction: Approximately a half of cutaneous melanoma has a BRAF V600E mutation and benefits from treatment with BRAF and MEK inhibitors, showing rapid tumor regression. However, most of these patients had progression ...
Avaliação da heterogeneidade intratumoral de mutações no gene kit em melanoma acral-lentiginoso
(Universidade Federal de São Paulo (UNIFESP), 2014-04-12)
Introduction: Melanoma is a malignant transformation of melanocytes. Acral lentiginous melanoma subtype occur more often in Afro-descendants and Asian population and have a more aggressive biologic nature than other subtypes. ...
A Time-Based and Intratumoral Proteomic Assessment of a Recurrent Glioblastoma Multiforme
(Frontiers Media, 2017)
Novel near-diploid ovarian cancer cell line derived from a highly aneuploid metastatic ovarian tumor
(PLoS, 2017)
A new ovarian near-diploid cell line, OVDM1, was derived from a highly aneuploid serous ovarian metastatic adenocarcinoma. A metastatic tumor was obtained from a 47-year-old Ashkenazi Jewish patient three years after the ...
Characterization of heterogeneous response to chemotherapy by perturbation-based modeling of fluorescent sphingolipid metabolism in cancer cell subpopulations
(2017)
Cancer treatments options are limited by the generation of therapy resistance, which is due by intratumoral heterogeneity in cell response. The study of resistance requires biosensors able to report the response at the ...
Genetic and epigenetic determinants of B-cell lymphoma evolution
(Lippincott Williams, 2016-05)
The success of targeted therapies fostered the development of increasingly specific and effective therapeutics for B-cell malignancies. However, cancer plasticity facilitates disease relapse, whereby intratumoral heterogeneity ...
CD4+, CD8+, FoxP3+ and HSP60+ Expressions in Cellular Infiltrate of Canine Mammary Carcinoma in Mixed Tumor
(Universidade Federal do Rio Grande do Sul, 2017)
Análisis molecular de la multifocalidad en cáncer de próstata como proceso de entendimiento del modelo de carcinogénesis de la enfermedad
(2019-06-07)
El cáncer de próstata (CaP) es una enfermedad multifocal heterogénea histológica y molecularmente, tanto a nivel interindividual como intraindividual cuya biología no está bien entendida. A partir del uso de muestras FFPE ...
Direct and indirect photodynamic therapy effects on the cellular and molecular components of the tumor microenvironment
(Elsevier Science, 2012-10)
Photodynamic therapy (PDT) is a novel cancer treatment. It involves the activation of a photosensitizer (PS) with light of specific wavelength, which interacts with molecular oxygen to generate singlet oxygen and other ...