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Artificial Itelligence Teaches Drugs to Target Proteins by Tackling the Induced Folding Problem
(American Chemical Society, 2020-06-17)
We explore the possibility of a deep learning (DL) platform that steers drug design to target proteins by inducing binding-competent conformations. We deal with the fact that target proteins are usually not fixed targets ...
Stabilization of partially folded states in protein folding/misfolding transitions by hydrostatic pressure
(Associação Brasileira de Divulgação Científica, 2019)
The key role of electrostatic interactions in the induced folding in RNA recognition by DCL1-A
(Royal Society of Chemistry, 2018-03)
The intrinsically disordered protein domain DCL1-A is the first report of a complete double stranded RNA binding domain folding upon binding. DCL1-A recognizes the dsRNA by acquiring a well-folded structure after engagement ...
Stability and folding studies of the N-domain of troponin C. Evidence for the formation of an intermediate
(Elsevier Science IncNew YorkEUA, 2004)
The principle of minimal episteric distortion of the water matrix and its role in protein folding
(American Institute Of Physics, 2013-08)
A significant episteric (around a solid) distortion of the hydrogen-bond structure of water is promoted by solutes with nanoscale surface detail and physico-chemical complexity, such as soluble natural proteins. These ...
Structural characteristics of the TPR Protein-Hsp90 interaction: A new target in biotechnology
(Bentham Science Publishers, 2018)
Nature employs multiple repeat protein scaffolds in order to promote proteinprotein interactions. In this sense, TPR proteins participate in different natural pathways, especially in diverse processes of eukaryotic cells. ...
Human Hsp70/Hsp90 Organizing Protein (Hop) D456G Is a Mixture of Monomeric and Dimeric Species
(Bentham Science Publ LtdSharjahEmirados Árabes Unidos, 2010)
Water promotes the sealing of nanoscale packing defects in folding proteins
(Iop Publishing, 2014-05)
A net dipole moment is shown to arise from a non-Debye component of water polarization created by nanoscale packing defects on the protein surface. Accordingly, the protein electrostatic field exerts a torque on the induced ...
Knots can impair protein degradation by ATP-dependent proteases
(National Academy of Sciences, 2017)
ATP-dependent proteases translocate proteins through a narrow pore for their controlled destruction. However, how a protein substrate containing a knotted topology affects this process remains unknown. Here, we characterized ...