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Mostrando ítems 1-10 de 2052
Tackling the cytokine storm in COVID-19, challenges and hopes
The outbreak of Coronavirus disease 2019 (COVID-19) is the current world health concern, presenting a public
health dilemma with ascending morbidity and mortality rates exceeding any previous viral spread, without a
standard ...
Rethinking interleukin-6 blockade for treatment of COVID-19
Interleukin-6 (IL-6) is a pleiotropic cytokine with effects in immune regulation, inflammation, and infection. The
use of drugs that inhibit IL-6 biological activity has been proposed as a treatment for patients with ...
Estudo da influência da infecção pelo HCV na ocorrência de inibidores em pacientes com Hemofilia A: avaliação de biomarcadores da resposta imune
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE MICROBIOLOGIAPrograma de Pós-Graduação em MicrobiologiaUFMG, 2020-02-28)
Patients with hemophilia A were at high risk of acquiring blood-borne infectious diseases, such as HCV, until the mid-1990s. This problem has been overcome and currently the development of FVIII inhibitors (anti-FVIII) ...
Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFN gamma production
(NATL ACAD SCIENCES, 2009)
IL-23/IL-17-induced neutrophil recruitment plays a pivotal role in rheumatoid arthritis (RA). However, the mechanism of the neutrophil recruitment is obscure. Here we report that prostaglandin enhances the IL-23/IL-17-induced ...
ETP-46321, a dual p110?/? class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis
Class IA phosphoinositide 3-kinases (PI3Ks) are essential to function of normal and tumor cells, and to modulate immune responses. T lymphocytes express high levels of p110? and p110? class IA PI3K. Whereas the functioning ...
Cytokine profile and FVIII inhibitors development in haemophilia A
(Blackwell Science, 2018)
Electrical stimulation induces IL-6 in skeletal muscle through extracellular ATP by activating Ca2 signals and an IL-6 autocrine loop
(American Physiological Society, 2014)
S. Electrical stimulation induces IL-6 in skeletal muscle through
extracellular ATP by activating Ca2 signals and an IL-6 autocrine
loop. Am J Physiol Endocrinol Metab 306: E869 –E882, 2014. First
published February ...
The Potential of p38 MAPK Inhibitors to Modulate Periodontal Infections
(Bentham Science Publ Ltd, 2009-01-01)
Periodontal disease initiation and progression occurs as a consequence of the host immune inflammatory response to oral pathogens. The innate and acquired immune systems are critical for the proper immune response. LPS, ...
Enhancement of the pulmonary allergic granulocyte recruitment in rats exposed to DMTI-II, a Kunitz-type inhibitor-isolated from Dimorphandra mollis seeds
(Elsevier Science BvAmsterdamHolanda, 2011)