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Insulin-like growth factors (IGFs) and IGF binding proteins-1, -2, and -3 in newborn serum: Relationships to fetoplacental growth at term
(Elsevier Ireland Ltd, 1996)
Cord sera were obtained from term, Chilean newborns exhibiting various patterns of intrauterine growth and assayed for IGF-1, IGF-2, IGFBP-1, IGFBP-2, and IGFBP-3 by specific radioimmunoassays (RIA). Serum levels of each ...
Fisiologia do eixo GH-sistema IGF
(Sociedade Brasileira de Endocrinologia e Metabologia, 2008)
O crescimento, principal característica da infância e da adolescência, apresenta padrão semelhante na maioria dos indivíduos. A herança genética e os componentes do eixo GH-IGF são os fatores que diretamente influenciam ...
Evaluation of the insulin-like growth factors (IGF) IGF-I and IGF binding protein 3 in patients at high risk for breast cancer
(ELSEVIER SCIENCE INC, 2011)
Our data suggest that serum concentrations of insulin-like growth factor I and insulin-like growth factor binding protein 3 do not correlate with breast cancer development. (Fertil Steril (R) 2011;95:2753-5. (C)2011 by ...
IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005-11-04)
Hyperosmotic stress stimulates a rapid and pronounced apoptosis in cardiac myocytes which is attenuated by insulin-like growth factor-1 (IGF-1). Because in these cells IGF-1 induces intracellular Ca2+ increase, we assessed ...
Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability
(Wiley Blackwell Publishing, Inc, 2016-04)
Mutations in multiple genes of the growth hormone/IGF-I axis have been identified in syndromes marked by growth failure. However, no pathogenic human mutations have been reported in the six high-affinity IGF-binding proteins ...
Use of pregnancy-associated plasma protein-A during oocyte in vitro maturation increases IGF-1 and affects the transcriptional profile of cumulus cells and embryos from Nelore cows
(2019-01-01)
Insulin-like growth factor 1 (IGF-1) activity is established by the regulation of IGF binding protein activity, which blocks IGF-1 functions, whereas pregnancy-associated plasma protein-A (PAPP-A) improves IGF-1 bioavailability ...