Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteins

Gabriel Amador Aguirre; Irene Martín Del Estal; María Inmaculada Castilla de Cortázar Larrea; José Luis González Guerra

Artículo

Registro en:

19326203

10.1371/journal.pone.0181760

http://hdl.handle.net/11285/630439

https://repositorioslatinoamericanos.uchile.cl/handle/2250/4196576

Autor

Gabriel Amador Aguirre

Irene Martín Del Estal

María Inmaculada Castilla de Cortázar Larrea

José Luis González Guerra

Institución

Instituto Tecnológico de Monterrey (México)

Materias

angiotensin II

calcium

connective tissue growth factor

somatomedin B receptor

somatomedin binding protein 1

somatomedin binding protein 2

somatomedin binding protein 3

somatomedin binding protein 4

somatomedin binding protein 5

somatomedin binding protein 6

somatomedin C

somatomedin C receptor

Article

coronary artery blood flow

gene

heart muscle contractility

heart muscle fibrosis

male

mouse

nonhuman

protein blood level

real time polymerase chain reaction

animal

gene expression regulation

Animals

Gene Expression Regulation

Hemodynamics

Insulin-Like Growth Factor I

Mice, Transgenic

Myocardial Contraction

Myocardium

Organ Size

Perfusion

Real-Time Polymerase Chain Reaction

Vasoconstriction

Vasodilation

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Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteins

Registro en:

Autor

Institución

Materias

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