Search
Now showing items 1-10 of 1498
Construção de híbridos dos interferons humanos beta e alfa2: papel das alfa-helices e alças na atividade biológica
(Universidade Federal de Minas GeraisUFMG, 2005-05-13)
Interferons are proteins involved in the organism defense processes, derived from cellular responses to microorganisms, tumors and antigens and are classified in type I, comprehending the IFN-, IFN-, IFN-, IFN-, IFN- and ...
Compuestos naturales y sintéticos que modulen la actividad biológica de los interferones de tipo I: análisis mediante una nueva herramienta biológica
(2014-05-03)
Los interferones son importantes glicoproteínas del sistema inmunológico, ampliamente utilizados como biofármacos para el tratamiento de diversas patologías. En este trabajo de tesis se desarrolló un ensayo de gen reportero ...
Endogenous accumulation of IFN-gamma in IFN-gamma-R-/- mice increases resistance to B16F10-Nex2 murine melanoma: a model for direct IFN-gamma anti-tumor cytotoxicity in vitro and in vivo
(Taylor & Francis As, 2002-06-01)
Syngeneic IFN-gamma - / - and IRF-1 - / - mice are very sensitive to B16F10-Nex2 murine melanoma cells implanted subcutaneously. in contrast, IFN-gamma-R - / - (GRKO) mice are remarkably resistant to tumor development. ...
Type I IFN deficiency: an immunological characteristic of severe COVID-19 patients
Recently, a paper published in Science by Hadjadj et al. reported
that type I interferon (IFN) deficiency, could be a hallmark of
severe coronavirus disease 2019 (COVID-19) caused by severe
acute respiratory syndrome ...
Papel do IFN- e da iNOS na patogênese do dengue experimental
(Universidade Federal de Minas GeraisUFMG, 2009-06-08)
Dengue is currently the most important mosquito-borne disease that affects humans and constitutes a serious world health problem. The lack of specific treatment and vaccine, and the incipient knowledge about pathogenesis ...
Genetic lesions of type i interferon signalling in human antiviral immunity
The concept that type I interferons (IFN-I) are essential to antiviral immunity
derives from studies on animal models and cell lines. Virtually all pathogenic
viruses have evolved countermeasures to IFN-I restriction, ...
Papel do IFN-y e do óxido nítrico na patogênese do dengue experimental em camundongos
(Universidade Federal de Minas GeraisUFMG, 2007-08-03)
Dengue is currently the most important mosquito-borne disease that affects humans and constitutes a serious world health problem. Although knowledge about the disease pathogenesis is incipient, an important role is attributed ...
The landscape of IFN/ISG signaling in HIV-1-infected macrophages and its possible role in the HIV-1 latency
(MDPI, 2021)
A key characteristic of Human immunodeficiency virus type 1 (HIV-1) infection is the generation of latent viral reservoirs, which have been associated with chronic immune activation and sustained inflammation. Macrophages ...