In trypanosomatids the involvement of mitochondrial complex I in NADH oxidation has long been debated. Here, we took advantage of natural Trypanosoma cruzi mutants which present conspicuous deletions in ND4, ND5 and ND7 ...

Parkinson?s disease (PD) is the second most prevalent neurodegenerative disorder, and it is characterized by the progressive degeneration of the dopaminergic neurons located in the substantia nigra pars compacta, striatum ...

This study, in an experimental model of type I Diabetes Mellitus in rats, deals with the mitochondrial production rates and steady-state concentrations of H2O2 and NO, and ATP levels as part of a network of signaling ...

The aim was to study heart mitochondrial function in the early stages of Diabetes (DM) which was induced by a single dose of Streptozoticin (60 mg/kg,ip) in male Wistar rats. Glycemia was determined 72 h after injection ...

Objectives: To study different metabolic parameters of the mitochondrialpopulation present in the villous trophoblast in the human termplacenta.Methods: This study was approved by the ethics committee of HospitalNacional ...

Mitochondria are the specialized organelles for energy metabolism, but, as a typical example of system biology, they also activate a multiplicity of pathways that modulate cell proliferation and mitochondrial biogenesis ...

Due to the high metabolic demands of the placental tissue during gestation, we decide to analyzed the mitochondrial bioenergetic functions in the human term placenta. Different mitochondrial morphological parameters, ...