Buscar
Mostrando ítems 1-10 de 92
Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating a-asarone-based HMG-CoA reductase inhibitors
(2013-01-30)
A series of a-asarone-based analogues was designed by conducting docking experiments with published
crystal structures of human HMG-CoA reductase. Indeed, synthesis and evaluation of this series showed a
highly ...
Design, synthesis, and docking of highly hypolipidemic agents:Schizosaccharomyces pombe as a new model for evaluating a-asarone-based HMG-CoA reductase inhibitors
(2013-02-26)
A series of a-asarone-based analogues was designed by conducting docking experiments with published
crystal structures of human HMG-CoA reductase. Indeed, synthesis and evaluation of this series showed a
highly ...
IAF, QGF, and QDF peptides exhibit cholesterol-lowering activity through a statin-like HMG-CoA reductase regulation mechanism: In silico and in vitro approach
(2021-10-01)
In this study, in silico approaches are employed to investigate the binding mechanism of peptides derived from cowpea β-vignin and HMG-CoA reductase. With the obtained information, we designed synthetic peptides to evaluate ...
In vitro and in silico studies of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitory activity of the cowpea Gln-Asp-Phe peptide
(2018-09-01)
Previous studies have shown that cowpea protein positively interferes with cholesterol metabolism. In this study, we evaluated the ability of the fraction containing peptides of <3 kDa, as well as that of the Gln-Asp-Phe ...
Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating a-asarone-based HMG-CoA reductase inhibitors
(2012-11-28)
A series of a-asarone-based analogues was designed by conducting docking experiments with published
crystal structures of human HMG-CoA reductase. Indeed, synthesis and evaluation of this series showed a
highly ...
Use of virtual screening, flexible docking, and molecular interaction fields to design novel HMG-CoA reductase inhibitors for the treatment of hypercholesterolemia
(AMER CHEMICAL SOC, 2008)
Dietary changes associated with drug therapy can reduce high serum cholesterol levels and dramatically decrease the risk of coronary artery disease, stroke, and overall mortality. Statins are hypolipemic drugs that are ...
Pravastatin reduces myocardial lesions induced by acute inhibition of nitric oxide biosynthesis in normocholesterolemic rats
(Elsevier Sci Ireland LtdClareIrlanda, 2001)
Processo de conversão de substrato renovável por aspergillus terreus UCP 0076 na biossíntese do inibidor da HMG-CoA redutase e intermediários.
(Universidade Católica de Pernambuco, 2021-03-08)
HMG-CoA reductase (3-hydroxy-3-methylglutaryl-coenzyme reductase) is the enzyme
that has a limiting role in cholesterol biosynthesis. Among the HMG-CoA reductase
inhibitory molecules, statins stand out, such as simvastatin, ...
El perfil de seguridad de las estatinas
(Sociedad Médica de Santiago, 2001)
Influence of the HMG-CoA reductase (TTA)n repeat gene polymorphism on the effects of atorvastatin in coronary artery disease patients
(2008)
Background Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase have been clinically used for lowering total and low-density lipoprotein cholesterol (LDL-C). Interindividual pharmacological differences ...