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Estrutura e variabilidade da região 3’não-traduzida dos genes HLA-A, HLA-C e HLA-G e perfil de ligação de microRNAs
(Universidade Estadual Paulista (Unesp), 2018-02-26)
O complexo gênico de Antígenos Leucocitário Humanos (HLA) é a região mais variável do genoma humano. Os genes HLA de classe I são divididos em clássicos e não clássicos, a depender de suas funções primárias, níveis de ...
HLA-F coding and regulatory segments variability determined by massively parallel sequencing procedures in a Brazilian population sample
(2016-10-01)
Human Leucocyte Antigen F (HLA-F) is a non-classical HLA class I gene distinguished from its classical counterparts by low allelic polymorphism and distinctive expression patterns. Its exact function remains unknown. It ...
Identification of two novel alleles HLA-B*3569 and -B*4450 and confirmation of HLA-A*2631 in the Brazilian population
(Blackwell PublishingOxfordInglaterra, 2007)
Hla-C genetic diversity and evolutionary insights in two samples from Brazil and Benin
(2020-01-01)
Human leukocyte antigen-C (HLA-C) is a classical HLA class I molecule that binds and presents peptides to cytotoxic T lymphocytes in the cell surface. HLA-C has a dual function because it also interacts with Killer-cell ...
HLA class II polymorphism in Brazilian populations
(2005)
The investigation of the distribution and frequency of HLA (Human Leukocyte Antigen) genes in presumably healthy
populations is important to evaluate the participation of these genes in the susceptibility and protection ...
Low variability at the HLA-promoter region in the Brazilian population
(2016-02-01)
Little information has been reported regarding the regulatory region of the HLA-gene. Only a proximal segment (300 bp immediately before exon 1) has been described at IMGT/HLA database. We aimed to evaluate the genetic ...
HLA-DPB1 and HLA-C alleles are associated with leprosy in a Brazilian population
(2021-01-01)
Despite intense efforts, the number of new cases of leprosy has remained significantly high over the past 20 years. Host genetic background is strongly linked to the pathogenesis of this disease, which is caused by ...
HLA class II polymorphism in Brazilian populations
(Instituto de Ci??ncias da Sa??de/ Universidade Federal da Bahia, 2005-05)
Diversidade genética e variantes estruturais do bloco alfa do complexo principal de histocompatibilidade humano
(Universidade Estadual Paulista (Unesp), 2020-02-18)
O MHC humano possui cerca de 224 genes, a maioria deles está relacionada de alguma forma com o sistema imunitário. O bloco alfa do MHC humano compreende genes importantes do complexo HLA, como HLA-F, HLA-G e HLA-A. HLA-F ...