Artículos de revistas
Identification of two novel alleles HLA-B*3569 and -B*4450 and confirmation of HLA-A*2631 in the Brazilian population
Registro en:
Tissue Antigens. Blackwell Publishing, v. 69, n. 3, n. 273, n. 276, 2007.
0001-2815
WOS:000245041000012
10.1111/j.1399-0039.2006.00788.x
Autor
Abdeen, H
McErlean, C
Moraes, ME
Romero, M
Marques, SB
Goncales, AC
Guariento, EG
Middleton, D
Institución
Resumen
Two novel alleles, human leukocyte antigen (HLA)-B*3569, -B*4450 and a confirmatory sequence of HLA-A*2631 were identified during a routine typing for the Brazilian Bone Marrow Donor Registry. Sequence analysis of coding exons 2 and 3 revealed a single nucleotide substitution in HLA-B*3569 and two single nucleotide substitutions in HLA-B*4450, compared with closely related alleles. At the protein level, these substitutions result in a change of a single amino acid residue in each of HLA-B*3569 and -B*4450 at positions 74 (Arg > Pro) and 80 (Thr > Ile), respectively. These variations are located in the highly polymorphic region at the end of the alpha(1) domain of the HLA molecule. It appears that HLA-B*3569 arose from the analogous HLA-B*3510 through a point mutation. However, HLA-B*4450 may have arisen from HLA-B*440301 and -B*4425 by gene conversion. 69 3 273 276