Abstract Dicistronic MLV-based retroviral vectors, in which two IRESes independently initiate the translation of two proteins from a single RNA, have been shown to direct co-expression of proteins in several ...

The cerebellum is an important organ to study development in the central nervous system. When matured, the cerebellum presents a well-defined three-layered cortex. Its development initiates during the embryonic period and ...

The role played by glial cells in the development of the central nervous system is not completely understood and the interaction of those cells with neurons is extremely important to the correct development of the brain. ...

Degeneration of motor neurons, glial cell reactivity, and vascular alterations in the CNS are important neuropathological features of amyotrophic lateral sclerosis (ALS). Immune cells trafficking from the blood also ...

Várias doenças humanas atualmente conhecidas têm causas genéticas. Uma maneira de se entender as alterações moleculares que levam a essas doenças é através da análise da disfunção de um gene, que pode ser feito usando ...

Serous (granular or venom) glands occur in the skin of almost all species of adult amphibians, and are thought to be the source of a great diversity of chemical compounds. Despite recent advances in their chemistry, odorous ...

The Subventricular zone (SVZ) is the site of adult neurogenesis to the olfactory bulb (OB). SVZ progenitors generate mainly two types of interneurons that integrate in the OB: granular and periglomerular (PG) neurons. ...

Existen múltiples evidencias de alteraciones neuronales y gliales en etapas avanzadas de la enfe-medad de Alzheimer con abundantes depósitos cerebrales de beta amiloide, aunque hay pocos datos de cambios tempranos que ...

Methylglyoxal (MG) is a α-oxoaldehyde compound formed mainly as co-product from glycolysis. Due its high glicative capacity, it is considered the major precursor of advanced glycation end-products (AGEs). Although the ...