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Plant growth-promoting genes can switch to be virulence factors via horizontal gene transfer
(Springer, 2018-10)
There are increasing evidences that horizontal gene transfer (HGT) is a critical mechanism of bacterial evolution, while its complete impact remains unclear. A main constraint of HGT effects on microbial evolution seems ...
Between the cross and the sword: the crisis of the gene concept
(2007-03)
Challenges to the gene concept have shown the difficulty of preserving the classical molecular concept, according to which a gene is a stretch of DNA encoding a functional product (polypeptide or RNA). The main difficulties ...
Development of a new promoter to avoid the silencing of genes in the production of recombinant antibodies in chinese hamster ovary cells
(BioMed Central Ltd., 2019)
Background: The production of recombinant proteins in mammalian cell lines is one of the most important areas in biopharmaceutical industry. Viral transcriptional promoters are widely used to express recombinant proteins ...
Divergent regulatory mechanisms in the response of respiratory chain component genes to carbohydrates suggests a model for gene evolution after duplication
(Landes Bioscience, 2009-04)
The biogenesis of the plant mitochondrial respiratory chain needs the coordinated synthesis and assembly of the products of more than 100 genes located in the nucleus and within the organelle. One of the factors that ...
Cre-loxP recombination vectors for promoter studies
(Pontificia Universidad Católica de Valparaíso, 2007)
Correlation of MGMT promoter methylation status with gene and protein expression levels in glioblastoma
(Faculdade de Medicina / USP, 2011)
OBJECTIVES: 1) To correlate the methylation status of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter to its gene and protein expression levels in glioblastoma and 2) to determine the most reliable method for ...