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Glycosomal Targets for Anti-Trypanosomatid Drug Discovery
(Bentham Science Publ Ltd, 2014-05-01)
Glycosomes are peroxisome-related organelles found in all kinetoplastid protists, including the human pathogenic species of the family Trypanosomatidae: Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. Glycosomes ...
Glycosomal targets for anti-trypanosomatid drug discovery
(2014-01-01)
Glycosomes are peroxisome-related organelles found in all kinetoplastid protists, including the human pathogenic species of the family Trypanosomatidae: Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp. Glycosomes ...
Glycosomal Targets for Anti-Trypanosomatid Drug Discovery
(Bentham Science Publ Ltd, 2014)
A novel stage-specific glycosomal nucleoside diphosphate kinase from Trypanosoma cruzi
(Czech Academy of Sciences. Institute of Parasitology, 2017-02)
Nucleoside diphosphate kinases (NDPK) are key enzymes involved in the intracellular nucleotide maintenance in all living organisms, especially in trypanosomatids which are unable to synthesise purines de novo. Four putative ...
Glycosomal bromodomain factor 1 from Trypanosoma cruzi enhances trypomastigote cell infection and intracellular amastigote growth
(Portland Press, 2015-12)
Acetylation is a ubiquitous protein modification present in prokaryotic and eukaryotic cells that participates in the regulation of many cellular processes. The bromodomain is the only domain known to bind acetylated lysine ...
Leishmania amazonensis Arginase Compartmentalization in the Glycosome Is Important for Parasite Infectivity
(PUBLIC LIBRARY SCIENCESAN FRANCISCO, 2012)
In Leishmania, de novo polyamine synthesis is initiated by the cleavage of L-arginine to urea and L-ornithine by the action of arginase (ARG, E.C. 3.5.3.1). Previous studies in L. major and L. mexicana showed that ARG is ...
Glycosomal Targets for Anti-Trypanosomatid Drug Discovery
(Bentham Science Publ Ltd, 2014)
Unique behavior of Trypanosoma cruzi mevalonate kinase: A conserved glycosomal enzyme involved in host cell invasion and signaling
(Nature Publishing Group, 2016)
Mevalonate kinase (MVK) is an essential enzyme acting in early steps of sterol isoprenoids biosynthesis, such as cholesterol in humans or ergosterol in trypanosomatids. MVK is conserved from bacteria to mammals, and localizes ...
A new trick for a conserved enzyme: mevalonate kinase, a glycosomal enzyme, can be secreted by Trypanosoma cruzi and modulate cell invasion and signaling. Is it another moonlighting enzyme?
(Universidade Federal de Minas GeraisBrasilICB - DEPARTAMENTO DE BIOLOGIA GERALUFMG, 2017-09)