Buscar
Mostrando ítems 1-10 de 11
Effects of Gabaergic phenols on phospholipid bilayers as evaluated by 1H-NMR
(Scientific Research Publishing, 2013-06)
The phenols propofol and thymol, and lately carvacrol, eugenol and chlorothymol, have been shown to act as positive allosteric modulators on GABAA receptor, which is the main inhibitory receptor of the central nervous ...
Lipophilicity of some GABAergic phenols and related compounds determined by HPLC and partition coefficients in different systems
(Elsevier Science, 2009-04-05)
Some phenolic compounds, like propofol and thymol, have been shown to act on the GABAA receptor. Taking into account the hydrophobicity of these compounds, their interaction with the membrane surrounding the receptor and ...
Effects of propofol and other GABAergic phenols on membrane molecular organization
(Elsevier Science, 2012-06)
GABAA receptor is the main inhibitory receptor of the central nervous system. The phenols propofol and thymol have been shown to act on this receptor. GABAA is an intrinsic protein, the activity of which may be affected ...
Neuroprotective effects of gabaergic phenols correlated with their pharmacological and antioxidant properties
(Pergamon-Elsevier Science Ltd, 2017-04-15)
Aims. Various investigations have demonstrated the protective capacity of general anesthetics as neuroprotective agents. The effects of propofol against ischemia are known to reside in its antioxidant properties and its ...
Effects of gabergic phenols on the dynamic and structure of lipid bilayers: A molecular dynamic simulation approach
(Public Library of Science, 2019-06)
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the vertebrate and invertebrate nervous system. GABAA receptors are activated by GABA and their agonists, and modulated by a wide variety of recognized ...
Perfil sobre el sistema nervioso central de vitexina-O-glucósido y una fracción rica en flavonoides y saponinas obtenida del extracto de Passiflora quadrangularis L
(Universidad Nacional de ColombiaBogotá - Ciencias - Maestría en Ciencias - FarmacologíaFacultad de CienciasBogotá, ColombiaUniversidad Nacional de Colombia - Sede Bogotá, 2022-12-13)
El objetivo de este estudio fue contribuir con el conocimiento de la actividad sobre el sistema nervioso central de la especie Passiflora quadrangularis Linn, evaluando los efectos del metabolito vitexina-2”O-glucósido y ...
Determinación de los efectos antihipertensivos de fracciones aisladas de Passiflora quadrangularis L. en murinos
(Bogotá - Ciencias - Doctorado en Ciencias FarmacéuticasDepartamento de FarmaciaUniversidad Nacional de Colombia - Sede Bogotá, 2020-08-28)
El objetivo del presente trabajo fue establecer el efecto cardiovascular de fracciones y compuestos aislados de Passiflora quadrangularis L. Para ello se realizó el fraccionamiento e identificación de compuestos del extracto ...