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Epi-nutrients in the oviductal environment: Folate levels and differential gene expression of its receptors and transporters in the bovine oviduct
(Elsevier, 2018-10)
Recent studies have demonstrated that the oviductal environment plays an active role in modulating the epigenetic marks of the preimplantation embryo genome, but the molecular factors that mediate this epigenetic effect ...
Metformin and cancer: Between the bioenergetic disturbances and the antifolate activity
(Elsevier, 2015)
For decades, metformin has been the first-line drug for the treatment of type II diabetes mellitus, and it thus is the most widely prescribed antihyperglycemic drug. Retrospective studies associate the use of metformin ...
Fatty acid and lipid metabolism in liver of pregnant mice and their offspring is influenced by unbalanced folates/vitamin B12 diets
(Elsevier, 2020)
Micronutrients (folates and vitamin B12) and long chain polyunsaturated fatty acids (LC-PUFAs) are linked through the one carbon cycle. We studied the effects of pre and postnatal high FA/low B12 diets (HFLB12) on hepatic ...
Factores determinantes del estado nutricional del folato y el rol de la variante genética C677T de la enzima metilen tetrahidrofolato reductasa (MTHFR)Determinants of folate nutritional status and the role of the genetic variation of C677T methylene tetrahydrofolate reductase (MTHFR) enzyme
(Sociedad Chilena de Nutrición, Bromatología y ToxicologíaAlimentación y Nutrición HumanaSantiago de Chile, Chile, 2021)
Búsqueda de selección en los Polimorfismos 1298a>C (C.1286a>C) (RS1801131) (P.E429A) y 677C>T (C.665C>T) (RS1801133) (P.A222V) del gen de la Metilentetrahidrofolato Reductasa (MTHFR) en una población colombiana
(Universidad del RosarioMaestría en Ciencias con Énfasis en Genética HumanaFacultad de medicina, 2018)
Folate is not synthesized by humans, but can be found in natural and synthetic sources such as folic acid; its importance lies in the participation in the maintenance of cellular homeostasis, gene regulation processes, ...
Encapsulação do paclitaxel em lipossomas recobertos com folato aumenta a captação celular e o efeito antitumoral em modelo experimental de tumor de mama
(Universidade Federal de Minas GeraisBrasilFARMACIA - FACULDADE DE FARMACIAPrograma de Pós-Graduação em Ciências FarmacêuticasUFMG, 2018-10-30)
Paclitaxel (PTX) is an effective chemotherapeutic agent widely used in breast cancer treatment. Nevertheless, the low solubility of the drug and the side effects of commercialformulations available limit their clinic use. ...
Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism
(Nature Publishing Group, 2017-08)
The folate-driven one-carbon (1C) cycle is a fundamental metabolic hub in cells that enables the synthesis of nucleotides and amino acids and epigenetic modifications. This cycle might also release formaldehyde, a potent ...
Epigenetics in type 1 diabetes: TNFa gene promoter methylation status in Chilean patients with type 1 diabetes mellitus
(Cambridge University Press, 2016)
© The Authors 2016. TNF-α is a pro-inflammatory cytokine that is involved in type 1 diabetes (T1D) pathogenesis. The TNFa gene is subject of epigenetic regulation in which folate and homocysteine are important molecules ...