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Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors—time for new definitions
(2021)
Abstract
Striated muscle is a highly plastic and regenerative organ that regulates body movement, temperature, and metabolism—all the functions needed for an individual’s health and well-being. The muscle ...
Evolving Roles of Muscle-Resident Fibro-Adipogenic Progenitors in Health, Regeneration, Neuromuscular Disorders, and Aging
(2021)
Normal skeletal muscle functions are affected following trauma, chronic diseases, inherited neuromuscular disorders, aging, and cachexia, hampering the daily activities and quality of life of the affected patients. The ...
Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered
(2017)
PDGFR alpha regulates several cellular processes, and exacerbated PDGF signaling cause fibrosis in different tissues. Different research groups have shown that fibro/adipogenic progenitors (FAPs) are responsible for ...