Articulo
Fibro/adipogenic progenitors safeguard themselves: a novel mechanism to reduce fibrosis is discovered
Fecha
2017Registro en:
1150106
WOS:000408036800009
Institución
Resumen
PDGFR alpha regulates several cellular processes, and exacerbated PDGF signaling cause fibrosis in different tissues. Different research groups have shown that fibro/adipogenic progenitors (FAPs) are responsible for pathological fibrosis found in skeletal muscle disorders. Rando's Lab describes that an intronic polyadenylation of Pdgfra regulates FAPs activity, and therefore fibrosis. This discovery opens a new potential target for treating fibrosis. Keywords. Author Keywords:Fibrosis PDGFR alpha Fibro/adipogenic progenitors Muscle regeneration Polyadenylation
KeyWords Plus:CONNECTIVE-TISSUE FIBROBLASTS MUSCLE FIBROSIS SKELETAL-MUSCLE SATELLITE CELLS PDGFR-ALPHA MYOGENESIS DYSTROPHY INJURY