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Free drug theory
(Springer, 2021)
The free drug theory (sometimes also termed free drug hypothesis) provides a conceptual framework increasingly used to understand pharmacokinetics/pharmacodynamics (PK/PD) relationships [1]. It underlines the central role ...
Drug Binding to Plasma Proteins
(Springer Nature Switzerland AG, 2021)
After absorption, most drugs will distribute heterogeneouslyacross tissues and organs, with the total drug concentration in plasmagenerally not being representative of the total concentration in other tissues.The main ...
Introduction: Biopharmaceutics and pharmacokinetics
(Springer Nature Switzerland AG, 2018)
Biopharmaceutics and pharmacokinetics are pharmaceutical disciplines useful to improve the outcome of drug therapies, assist drug product development, and establish pharmacokinetics-pharmacodynamics models and in vitro-in ...
Computational modeling and experimental facts of mixed self-assembly systems
(Bentham Science Publishers, 2016-09)
The formation of liposomes, nanoparticle micelles, and related systems by mixtures of drugs and/or surfactants is of major relevance for the design of drug delivery systems. We can design new systems using different ...
Electrochemical and microsomal production of free radicals from 1,2,5-oxadiazole N-oxide as potential antiprotozoal drugs
(PERGAMON-ELSEVIER SCIENCE LTD, 2003-01-01)
The electron spin resonance (ESR) spectra of free radicals obtained by electrolytic or microsomal reduction of several potential antiprotozoal 1,2,5-oxadiazoles were characterized and analyzed. Ab initio molecular orbital ...
Anticonvulsant activity of ringed enaminones: a QSAR study
(Wiley VCH Verlag, 2009-12)
The formalism of the QSAR Theory is employed to establish mathematical relationships that link the molecular structure of ringed enaminones to their observed antiepileptic activity. The design of predictive linear regression ...
Electrochemical, ESR and theoretical insights into the free radical generation by 1,1'-hydrocarbylenebisindazoles and its evaluation as potential bio-active compounds
(2012)
A comprehensive multidisciplinary study is conducted here in order to assess the electrochemical behavior of a series of 1,1'-hydrocarbylenebisindazoles derivatives and its potential use as anti-T.cruzi drugs. At first, ...
Pessoas em situação de rua e suas representações sobre drogas.
(Escola de Enfermagem e Saúde da Universidade Federal da BahiaPrograma de Pós-Graduação em Enfermagem e SaúdeUFBAbrasil, 2019-05-17)
A vida em situação de rua e o consumo de drogas são fenômenos globais, historicamente determinados por fatores econômicos, sociais e culturais. Ambos os fenômenos configuram síntese multifacetadas e dinâmicas que variam ...
Las drogas: políticas nacionales e internacionales de control. Una introducción crítica
(Bogotá: Universidad Católica de Colombia, 2015, 2015)
El control de drogas es un tema que durante décadas ha alimentado la violencia política en Colombia y contribuido a entronizar en nuestra cultura los anti-valores que soportan la industria del tráfico internacional de ...